Evidence map›Paper›PMID 9524119›Full record

ArticleThe EMBO journal1998

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals.

A M Scharenberg, O El-Hillal, D A Fruman, L O Beitz, Z Li, S Lin, I Gout, L C Cantley, D J Rawlings, J P Kinet

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed
25.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 427 citations in OpenAlex.

  1. Review
  2. Genes · 2023
    Review
  3. Acute Csk inhibition hinders B cell activation by constraining the PI3 kinase pathway.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  4. Review
  5. CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  6. Review
  7. Phospholipid subcellular localization and dynamics.The Journal of biological chemistry · 2018
    Review
  8. Review
  9. Review
  10. Article
  11. Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2015
    Review
  12. Article
  13. Review
  14. Phospholipase C-β in immune cells.Advances in biological regulation · 2013
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. An involvement of neurokinin-1 receptor in FcεRΙ-mediated RBL-2H3 mast cell activation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012
    Article

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

A M ScharenbergLaboratory of Allergy and Immunology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
O El-Hillal
D A Fruman
L O Beitz
Z Li
S Lin
I Gout
L C Cantley
D J Rawlings
J P Kinet
Beth Israel Deaconess Medical Center · USUniversity of California, Los Angeles · USInstitute of Molecular Biology and Genetics · UA

Funding

The Role of PI3K in Growth RegulationR01GM041890 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI CANTLEY, LEWIS C. · 1990 to 2016
$4.1M
NIGMS NIH HHS R01 GM041890
6 · The paper itself

Abstract

Tec family non-receptor tyrosine kinases have been implicated in signal transduction events initiated by cell surface receptors from a broad range of cell types, including an essential role in B-cell development. A unique feature of several Tec members among known tyrosine kinases is the presence of an N-terminal pleckstrin homology (PH) domain. We directly demonstrate that phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3) interacting with the PH domain acts as an upstream activation signal for Tec kinases, resulting in Tec kinase-dependent phospholipase Cgamma (PLCgamma) tyrosine phosphorylation and inositol trisphosphate production. In addition, we show that this pathway is blocked when an SH2-containing inositol phosphatase (SHIP)-dependent inhibitory receptor is engaged. Together, our results suggest a general mechanism whereby PtdIns-3,4,5-P3 regulates receptor-dependent calcium signals through the function of Tec kinases.

Indexed as

PhosphoproteinsAgammaglobulinaemia Tyrosine KinaseAnimalsBlood ProteinsCalciumCell Line, TransformedEnzyme ActivationEnzyme InhibitorsFibroblastsInositol PhosphatesIsoenzymesMutationPhosphatidylinositol-3,4,5-Trisphosphate 5-PhosphatasesPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhosphoinositide-3 Kinase InhibitorsAgammaglobulinaemia Tyrosine KinaseBlood ProteinsCalciumemt protein-tyrosine kinaseEnzyme InhibitorsInositol PhosphatesINPPL1 protein, humanIsoenzymesphosphatidylinositol 3,4,5-triphosphatePhosphatidylinositol-3,4,5-Trisphosphate 5-PhosphatasesPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhosphoinositide-3 Kinase InhibitorsPhospholipase C gammaPhosphoproteinsPhosphoric Monoester Hydrolasesplatelet protein P47Protein-Tyrosine KinasesReceptors, Antigen, B-CellReceptors, IgGTec protein-tyrosine kinaseType C PhospholipasesTyrosine

Identifiers

PMID9524119
PMCPMC1170542
OpenAlexW2165742826

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.