ArticleProceedings of the National Academy of Sciences of the United States of America1998
Epithelial attachment alters the outcome of Helicobacter pylori infection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
92 citing papers in PubMed, 292 citations in OpenAlex.
- Review
- Managing dangerous liaisons: lessons fromJournal of bacteriology · 2026Review
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- Microbiota in the stomach and application of probiotics to gastroduodenal diseases.World journal of gastroenterology · 2022Review
- Lactate causes downregulation of Helicobacter pylori adhesin genes sabA and labA while dampening the production of proinflammatory cytokines.Scientific reports · 2022Article
- Review
- Article
- Review
- Helicobacter pylori: An Underrated Cause of Immune Thrombocytopenic Purpura. A Comprehensive Review.Cureus · 2019Review
- The Possible Role ofFrontiers in oncology · 2019Review
- Dynamic Expression of the BabA Adhesin and Its BabB Paralog during Helicobacter pylori Infection in Rhesus Macaques.Infection and immunity · 2017Article
- Host Determinants of Expression of the Helicobacter pylori BabA Adhesin.Scientific reports · 2017Article
- Insights into gastric neuroendocrine tumors burden.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2017Article
- Non-pharmacological treatment of Helicobacter pylori.World journal of gastrointestinal pharmacology and therapeutics · 2016Review
- Galectin-3 Plays an Important Role in Innate Immunity to Gastric Infection by Helicobacter pylori.Infection and immunity · 2016Article
- Review
- Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori.Cell host & microbe · 2016Article
- Systems-wide analyses of mucosal immune responses to Helicobacter pylori at the interface between pathogenicity and symbiosis.Gut microbes · 2016Review
- Alteration of the Helicobacter pylori membrane proteome in response to changes in environmental salt concentration.Proteomics. Clinical applications · 2015Article
- The Cell Shape-determining Csd6 Protein from Helicobacter pylori Constitutes a New Family of L,D-Carboxypeptidase.The Journal of biological chemistry · 2015Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetically defined in vivo models are needed to assess the importance of target cell attachment in bacterial pathogenesis. Gastric colonization by Helicobacter pylori in human populations is common and persistent, and has various outcomes including peptic ulcers and cancer. The impact of attachment on the course of infection was examined in transgenic mice expressing a human receptor for H. pylori in their gastric epithelium. Persistent infection by a clinical isolate occurred at comparable microbial densities in transgenic and nontransgenic littermates. However, microbial attachment in transgenic mice resulted in production of autoantibodies to Lewisx carbohydrate epitopes shared by bacteria and acid-secreting parietal cells, chronic gastritis, and parietal cell loss. This model should help identify bacterial and host genes that produce attachment-related pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.