ArticleProceedings of the National Academy of Sciences of the United States of America1998
An X chromosome gene regulates hematopoietic stem cell kinetics.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 91 citations in OpenAlex.
- X-linked competition - implications for human development and disease.Nature reviews. Genetics · 2025Review
- Toward telomere-to-telomere cat genomes for precision medicine and conservation biology.Genome research · 2024Review
- Epithelial Cell Transformation and Senescence as Indicators of Genome Aging: Current Advances and Unanswered Questions.International journal of molecular sciences · 2021Review
- Visualizing hematopoiesis as a stochastic process.Blood advances · 2018Article
- Concise Review: Age-Related Clonal Hematopoiesis: Stem Cells Tempting the Devil.Stem cells (Dayton, Ohio) · 2018Review
- Sex and Gender Differences Research Design for Basic, Clinical, and Population Studies: Essentials for Investigators.Endocrine reviews · 2018Review
- Trauma-Induced Acute X Chromosome Skewing in White Blood Cells Represents an Immuno-Modulatory Mechanism Unique to Females and a Likely Contributor to Sex-Based Outcome Differences.Shock (Augusta, Ga.) · 2017Article
- Selection of X-chromosome Inactivation Model.Cancer informatics · 2017Article
- Inherent X-Linked Genetic Variability and Cellular Mosaicism Unique to Females Contribute to Sex-Related Differences in the Innate Immune Response.Frontiers in immunology · 2017Article
- FARVATX: Family-Based Rare Variant Association Test for X-Linked Genes.Genetic epidemiology · 2016Article
- Clonal hematopoiesis as determined by the HUMARA assay is a marker for acquired mutations in epigenetic regulators in older women.Experimental hematology · 2016Article
- Article
- X-chromosome genetic association test accounting for X-inactivation, skewed X-inactivation, and escape from X-inactivation.Genetic epidemiology · 2014Article
- Article
- Article
- Human X-chromosome inactivation pattern distributions fit a model of genetically influenced choice better than models of completely random choice.European journal of human genetics : EJHG · 2013Article
- Female X-chromosome mosaicism for NOX2 deficiency presents unique inflammatory phenotype and improves outcome in polymicrobial sepsis.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Article
- Long-term outcome of hemizygous and heterozygous carriers of a germline GATA1 (G208R) mutation.Annals of hematology · 2011Article
- Skewing of X-inactivation ratios in blood cells of aging women is confirmed by independent methodologies.Blood · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Females are natural mosaics for X chromosome-linked genes. As X chromosome inactivation occurs randomly, the ratio of parental phenotypes among blood cells is approximately 1:1. Recently, however, ratios of greater than 3:1 have been observed in 38-56% of women over age 60. This could result from a depletion of hematopoietic stem cells (HSCs) with aging (and the maintenance of hematopoiesis by a few residual clones) or from myelodysplasia (the dominance of a neoplastic clone). Each possibility has major implications for chemotherapy and for transplantation in elderly patients. We report similar findings in longitudinal studies of female Safari cats and demonstrate that the excessive skewing that develops with aging results from a third mechanism that has no pathologic consequence, hemizygous selection. We show that there is a competitive advantage for all HSCs with a specific X chromosome phenotype and, thus, demonstrate that an X chromosome gene (or genes) regulates HSC replication, differentiation, and/or survival.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.