ArticleProceedings of the National Academy of Sciences of the United States of America1998
Archaeal translation initiation revisited: the initiation factor 2 and eukaryotic initiation factor 2B alpha-beta-delta subunit families.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Role of aIF5B in archaeal translation initiation.Nucleic acids research · 2022Article
- Homology-based reconstruction of regulatory networks for bacterial and archaeal genomes.Frontiers in microbiology · 2022Article
- Identification of a Novel Heterozygous Mutation in theFrontiers in bioengineering and biotechnology · 2022Article
- Cryo-EM study of an archaeal 30S initiation complex gives insights into evolution of translation initiation.Communications biology · 2020Article
- The Prodigal Compound: Return of Ribosyl 1,5-Bisphosphate as an Important Player in Metabolism.Microbiology and molecular biology reviews : MMBR · 2019Review
- Start Codon Recognition in Eukaryotic and Archaeal Translation Initiation: A Common Structural Core.International journal of molecular sciences · 2019Review
- eIF2A, an initiator tRNA carrier refractory to eIF2α kinases, functions synergistically with eIF5B.Cellular and molecular life sciences : CMLS · 2018Article
- A presumed homologue of the regulatory subunits of eIF2B functions as ribose-1,5-bisphosphate isomerase in Pyrococcus horikoshii OT3.Scientific reports · 2018Article
- Evolution of the archaeal and mammalian information processing systems: towards an archaeal model for human disease.Cellular and molecular life sciences : CMLS · 2017Review
- The Proteome and Lipidome of Thermococcus kodakarensis across the Stationary Phase.Archaea (Vancouver, B.C.) · 2016Article
- Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2.Nucleic acids research · 2015Article
- On how many fundamental kinds of cells are present on Earth: looking for phylogenetic traits that would allow the identification of the primary lines of descent.Journal of molecular evolution · 2014Article
- Structure of mediator of RhoA-dependent invasion (MRDI) explains its dual function as a metabolic enzyme and a mediator of cell invasion.Biochemistry · 2013Article
- Dynamic, ligand-dependent conformational change triggers reaction of ribose-1,5-bisphosphate isomerase from Thermococcus kodakarensis KOD1.The Journal of biological chemistry · 2012Article
- Structural dynamics of bacterial translation initiation factor IF2.The Journal of biological chemistry · 2012Article
- A new role for translation initiation factor 2 in maintaining genome integrity.PLoS genetics · 2012Article
- The last universal common ancestor (LUCA) and the ancestors of archaea and bacteria were progenotes.Journal of molecular evolution · 2011Article
- Identification and genomic analysis of transcription factors in archaeal genomes exemplifies their functional architecture and evolutionary origin.Molecular biology and evolution · 2010Article
- Agmatidine, a modified cytidine in the anticodon of archaeal tRNA(Ile), base pairs with adenosine but not with guanosine.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme.Molecular & cellular proteomics : MCP · 2009Article
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2 authors.
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Abstract
As the amount of available sequence data increases, it becomes apparent that our understanding of translation initiation is far from comprehensive and that prior conclusions concerning the origin of the process are wrong. Contrary to earlier conclusions, key elements of translation initiation originated at the Universal Ancestor stage, for homologous counterparts exist in all three primary taxa. Herein, we explore the evolutionary relationships among the components of bacterial initiation factor 2 (IF-2) and eukaryotic IF-2 (eIF-2)/eIF-2B, i.e., the initiation factors involved in introducing the initiator tRNA into the translation mechanism and performing the first step in the peptide chain elongation cycle. All Archaea appear to posses a fully functional eIF-2 molecule, but they lack the associated GTP recycling function, eIF-2B (a five-subunit molecule). Yet, the Archaea do posses members of the gene family defined by the (related) eIF-2B subunits alpha, beta, and delta, although these are not specifically related to any of the three eukaryotic subunits. Additional members of this family also occur in some (but by no means all) Bacteria and even in some eukaryotes. The functional significance of the other members of this family is unclear and requires experimental resolution. Similarly, the occurrence of bacterial IF-2-like molecules in all Archaea and in some eukaryotes further complicates the picture of translation initiation. Overall, these data lend further support to the suggestion that the rudiments of translation initiation were present at the Universal Ancestor stage.
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