ArticleProceedings of the National Academy of Sciences of the United States of America1998
Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Improved Assessment of Globularity of Protein Structures and the Ellipsoid Profile of the Biological Assemblies from the PDB.Biomolecules · 2023Article
- Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia.Nature communications · 2021Article
- Review
- TheGenes · 2021Review
- Characteristics, outcomes, prognostic factors and treatment of patients with T-cell prolymphocytic leukemia (T-PLL).Annals of oncology : official journal of the European Society for Medical Oncology · 2017Article
- Prioritizing genes for X-linked diseases using population exome data.Human molecular genetics · 2015Article
- A virtual pebble game to ensemble average graph rigidity.Algorithms for molecular biology : AMB · 2015Article
- Article
- TCL1 participates in early embryonic development and is overexpressed in human seminomas.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data.Journal of biomolecular NMR · 2000Article
- Tcl1 enhances Akt kinase activity and mediates its nuclear translocation.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Genomic analysis of human and mouse TCL1 loci reveals a complex of tightly clustered genes.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. The crystal structure of human recombinant MTCP-1 protein has been determined at 2.0 A resolution by using multiwavelength anomalous dispersion data from selenomethionine-enriched protein and refined to an R factor of 0.21. MTCP-1 folds into a compact eight-stranded beta barrel structure with a short helix between the fourth and fifth strands. The topology is unique. The structure of TCL-1 has been predicted by molecular modeling based on 40% amino acid sequence identity with MTCP-1. The identical residues are clustered inside the barrel and on the surface at one side of the barrel. The overall structure of MTCP-1 superficially resembles the structures of proteins in the lipocalin family and calycin superfamily. These proteins have diverse functions, including transport of retinol, fatty acids, chromophores, pheromones, synthesis of prostaglandin, immune modulation, and cell regulation. However, MTCP-1 differs in the topology of the beta strands. The structural similarity suggests that MTCP-1 and TCL-1 form a unique family of beta barrel proteins that is predicted to bind small hydrophobic ligands and function in cell regulation.
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