ArticleThe Journal of physiology1998
Non-genomic inhibition of human P2X7 purinoceptor by 17beta-oestradiol.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- Impact of Estrogen on Purinergic Signaling in Microvascular Disease.International journal of molecular sciences · 2025Review
- P2X7 receptor knockout does not alter renal function or prevent angiotensin II-induced kidney injury in F344 rats.Scientific reports · 2024Article
- Meningeal P2X7 Signaling Mediates Migraine-Related Intracranial Mechanical Hypersensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Meningeal P2X7 signaling mediates migraine-related intracranial mechanical hypersensitivity.bioRxiv : the preprint server for biology · 2023Article
- LPS-Induced Systemic Neonatal Inflammation: Blockage of P2X7R by BBG Decreases Mortality on Rat Pups and Oxidative Stress in Hippocampus of Adult Rats.Frontiers in behavioral neuroscience · 2019Article
- Genetic interaction of purinergic P2X7 receptor and ER-α polymorphisms in susceptibility to osteoporosis in Chinese postmenopausal women.Journal of bone and mineral metabolism · 2018Article
- Administration of 17β-Estradiol Improves Motoneuron Survival and Down-regulates Inflammasome Activation in Male SOD1(G93A) ALS Mice.Molecular neurobiology · 2017Article
- Ovariectomy uncovers purinergic receptor activation of endothelin-dependent natriuresis.American journal of physiology. Renal physiology · 2017Article
- P2X7 receptor antagonism in amyotrophic lateral sclerosis.Neural regeneration research · 2017Article
- Review
- Altered Expression of Genes Encoding Neurotransmitter Receptors in GnRH Neurons of Proestrous Mice.Frontiers in cellular neuroscience · 2016Article
- Caspase-1-mediated cytokine release from gestational tissues, placental, and cord blood.Frontiers in physiology · 2015Article
- Loss of P2X7 nucleotide receptor function leads to abnormal fat distribution in mice.Purinergic signalling · 2014Article
- Is pannexin the pore associated with the P2X7 receptor?Naunyn-Schmiedeberg's archives of pharmacology · 2013Article
- Interaction of purinergic receptors with GPCRs, ion channels, tyrosine kinase and steroid hormone receptors orchestrates cell function.Purinergic signalling · 2012Article
- Effect of P2X(7) receptor knockout on exocrine secretion of pancreas, salivary glands and lacrimal glands.The Journal of physiology · 2010Article
- Atypical P2X receptor pharmacology in two human osteoblast-like cell lines.British journal of pharmacology · 2009Article
- Estradiol inhibits the effects of extracellular ATP in human sperm by a non genomic mechanism of action.Purinergic signalling · 2005Article
- Modulation of mitochondrial Ca(2+) uptake by estrogen receptor agonists and antagonists.British journal of pharmacology · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Effects of oestrogen on the current evoked by ATP and benzoylbenzoyl ATP (BzATP) in CV-1 monkey kidney cells transformed by SV 40 (COS cells) expressing the human P2X7 (hP2X7) purinoceptor were studied using standard patch-clamp techniques. 2. 17beta-Oestradiol rapidly and reversibly inhibited the whole-cell hP2X7 receptor cation current. This inhibitory action resulted in a rightward shift of the dose-response curve to ATP and BzATP in the presence of physiological as well as low divalent cation concentrations. 3. The inhibitory effect of 17beta-oestradiol on the BzATP- or ATP-induced cation current was concentration dependent. The half-maximal inhibition was obtained with 3 microM 17beta-oestradiol. Progesterone and 17alpha-oestradiol had almost no effect on the hP2X7 receptor cation current. 4. The inhibition of the hP2X7 receptor cation current by 17beta-oestradiol did not depend on the membrane potential. 17beta-Oestradiol added to the extracellular side of outside-out patches inhibited BzATP-activated single-channel currents. 5. Activation of the hP2X7 receptor in both COS and U937 (human macrophage) cells did not induce the formation of large non-specific pores. 6. Since COS cells do not express endogenous nuclear oestrogen receptor, this study shows that, at pharmacological concentrations, 17beta-oestradiol inhibited the hP2X7 receptor cation channel in a non-genomic manner.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.