ArticleThe Journal of physiology1998
Cyclic ADP-ribose and calcium-induced calcium release regulate neurotransmitter release at a cholinergic synapse of Aplysia.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 94 citations in OpenAlex.
- Review
- Effect of bovine adenovirus 3 on mitochondria.Veterinary research · 2014Article
- Physiology and pathology of calcium signaling in the brain.Frontiers in pharmacology · 2012Article
- Glycosides, depression and suicidal behaviour: the role of glycoside-linked proteins.Molecules (Basel, Switzerland) · 2011Review
- Ryanodine receptors selectively contribute to the formation of taste-evoked calcium signals in mouse taste cells.The European journal of neuroscience · 2010Article
- Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38.The Journal of biological chemistry · 2009Article
- Transient receptor potential vanilloid subtype 1 channel mediated neuropeptide secretion and depressor effects: role of endoplasmic reticulum associated Ca2+ release receptors in rat dorsal root ganglion neurons.Journal of hypertension · 2008Article
- Nucleoplasmic reticulum is not essential in nuclear calcium signalling mediated by cyclic ADPribose in primary neurons.Pflugers Archiv : European journal of physiology · 2008Article
- Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes.Learning & memory (Cold Spring Harbor, N.Y.) · 2008Article
- The CD38-independent ADP-ribosyl cyclase from mouse brain synaptosomes: a comparative study of neonate and adult brain.The Biochemical journal · 2006Article
- Multiple signal transduction pathways mediated by 5-HT receptors.Molecular neurobiology · 2004Review
- Potentiation of quantal secretion by insulin-like growth factor-1 at developing motoneurons in Xenopus cell culture.The Journal of physiology · 2003Article
- Presynaptic ryanodine-sensitive calcium stores contribute to evoked neurotransmitter release at the basket cell-Purkinje cell synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Ca2+ influx-independent synaptic potentiation mediated by mitochondrial Na(+)-Ca2+ exchanger and protein kinase C.The Journal of cell biology · 2003Article
- The human immunodeficiency virus-1 protein Tat and its discrete fragments evoke selective release of acetylcholine from human and rat cerebrocortical terminals through species-specific mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Two intracellular pathways mediate metabotropic glutamate receptor-induced Ca2+ mobilization in dopamine neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Assessing the role of calcium-induced calcium release in short-term presynaptic plasticity at excitatory central synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Compartmental neurodegeneration and synaptic plasticity in the Wld(s) mutant mouse.The Journal of physiology · 2001Review
- Intracellular Ca(2+) and Ca(2+)/calmodulin-dependent kinase II mediate acute potentiation of neurotransmitter release by neurotrophin-3.The Journal of cell biology · 2000Article
- Functional coupling of Ca(2+) channels to ryanodine receptors at presynaptic terminals. Amplification of exocytosis and plasticity.The Journal of general physiology · 2000Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Presynaptic injection of cyclic ADP-ribose (cADPR), a modulator of the ryanodine receptor, increased the postsynaptic response evoked by a presynaptic spike at an identified cholinergic synapse in the buccal ganglion of Aplysia californica. 2. The statistical analysis of long duration postsynaptic responses evoked by square depolarizations of the voltage-clamped presynaptic neurone showed that the number of evoked acetylcholine (ACh) quanta released was increased following cADPR injection. 3. Overloading the presynaptic neurone with cADPR led to a transient increase of ACh release followed by a depression. 4. cADPR injections did not modify the presynaptic Ca2+ current triggering ACh release. 5. Ca2+ imaging with the fluorescent dye rhod-2 showed that cADPR injection rapidly increased the free intracellular Ca2+ concentration indicating that the effects of cADPR on ACh release might be related to Ca2+ release from intracellular stores. 6. Ryanodine and 8-amino-cADPR, a specific antagonist of cADPR, decreased ACh release. 7. ADP-ribosyl cyclase, which cyclizes NAD+ into cADPR, was present in the presynaptic neurone as shown by reverse transcriptase-polymerase chain reaction experiments. 8. Application of NAD+, the substrate of ADP-ribosyl cyclase, increased ACh release and this effect was prevented by both ryanodine and 8-amino-cADPR. 9. These results support the view that Ca(2+)-induced Ca2+ release might be involved in the build-up of the Ca2+ concentration which triggers ACh release, and thus that cADPR might have a role in transmitter release modulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.