ArticleThe Journal of physiology1998
Near-visible ultraviolet light induces a novel ubiquitous calcium-permeable cation current in mammalian cell lines.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Neuropsin, TRPV4 and intracellular calcium mediate intrinsic photosensitivity in corneal epithelial cells.The ocular surface · 2025Article
- Endogenous ion channels expressed in human embryonic kidney (HEK-293) cells.Pflugers Archiv : European journal of physiology · 2022Review
- Store-Operated CaInternational journal of molecular sciences · 2022Article
- From sunscreens to medicines: Can a dissipation hypothesis explain the beneficial aspects of many plant compounds?Phytotherapy research : PTR · 2020Review
- Silver ions promote blebs growth in U251 glioblastoma cell by activating nonselective cationic currents.Scientific reports · 2019Article
- X-ray irradiation activates K+ channels via H2O2 signaling.Scientific reports · 2015Article
- UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Pathophysiologically relevant levels of hydrogen peroxide induce glutamate-independent neurodegeneration that involves activation of transient receptor potential melastatin 7 channels.Antioxidants & redox signaling · 2011Article
- Activation of store-operated I(CRAC) by hydrogen peroxide.Cell calcium · 2010Article
- Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils.Cell calcium · 2008Article
- The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions.The Journal of cell biology · 2006Article
- Ultraviolet photoalteration of late Na+ current in guinea-pig ventricular myocytes.The Journal of membrane biology · 2006Article
- Excitatory and inhibitory circuitry in the superficial gray layer of the superior colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Receptor-mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD).The Journal of physiology · 2001Review
- "Light" reading: targeting tryptophans in cyclic nucleotide-gated channels.The Journal of general physiology · 2000Review
- Modification of cyclic nucleotide-gated ion channels by ultraviolet light.The Journal of general physiology · 2000Article
- Enhancement of NMDA receptor-mediated currents by light in rat neurones in vitro.The Journal of physiology · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. We studied the immediate and short-term effects of UV light in the near-visible range at the cellular and membrane level using the whole-cell patch-clamp technique in combination with digital fluorescence imaging. 2. Illumination with monochromatic UVA light (340-380 nm) induced a sustained non-saturable increase in membrane conductance dependent on wavelength and light intensity in several different mammalian cell types including RBL, mast, HEK, PC12 and 3T3 cells. 3. The current was non-selective for cations and permeable to Ca2+, but was inhibited by trivalent cations and was not due to the activation of an endogenous ion channel. We termed this novel current ILiNC for light-induced non-selective cation current. 4. A similar current was evoked by chemical peroxidants such as hydrogen peroxide and tertbutylhydroperoxide, but not by cytosolic oxidized glutathione. 5. The free-radical scavengers tocopherol (vitamin E) and ascorbic acid (vitamin C) significantly reduced the UV light effect. 6. The generation of the current was membrane delimited since it could be induced by the same UVA treatment in cell-free membrane patches showing a similar wavelength dependence. 7. These results suggest that ILiNC is activated by UVA light-induced generation of free radicals acting through lipid or protein peroxidation, and may represent a ubiquitous mechanism by which Na+ and Ca2+ can enter cells after phototoxic or free radical-induced membrane damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.