ArticleThe Journal of physiology1998
Two mechanisms for inward rectification of current flow through the purinoceptor P2X2 class of ATP-gated channels.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Mechanisms of ligand recognition and channel opening for P2X2 receptors in lipid nanodiscs.Science advances · 2026Article
- Mechanisms of ligand recognition and channel opening for P2X2 receptors in lipid nanodiscs.bioRxiv : the preprint server for biology · 2025Article
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- Article
- Hearing loss mutations alter the functional properties of human P2X2 receptor channels through distinct mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Voltage- and ATP-dependent structural rearrangements of the P2X2 receptor associated with the gating of the pore.The Journal of physiology · 2014Article
- Signal transmission within the P2X2 trimeric receptor.The Journal of general physiology · 2014Article
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- P2X receptor channels show threefold symmetry in ionic charge selectivity and unitary conductance.Nature neuroscience · 2011Article
- ATP-mediated potassium recycling in the cochlear supporting cells.Purinergic signalling · 2010Article
- Functional and structural identification of amino acid residues of the P2X2 receptor channel critical for the voltage- and [ATP]-dependent gating.The Journal of physiology · 2009Article
- Dynamic aspects of functional regulation of the ATP receptor channel P2X2.The Journal of physiology · 2009Review
- Polar residues in the second transmembrane domain of the rat P2X2 receptor that affect spontaneous gating, unitary conductance, and rectification.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Voltage- and [ATP]-dependent gating of the P2X(2) ATP receptor channel.The Journal of general physiology · 2009Article
- Opposite effects of zinc on human and rat P2X2 receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Contribution of extracellular negatively charged residues to ATP action and zinc modulation of rat P2X2 receptors.Journal of neurochemistry · 2008Article
- Responses of rat P2X2 receptors to ultrashort pulses of ATP provide insights into ATP binding and channel gating.The Journal of general physiology · 2007Article
- Regulation of the desensitization and ion selectivity of ATP-gated P2X2 channels by phosphoinositides.The Journal of physiology · 2006Article
- Biophysics of P2X receptors.Pflugers Archiv : European journal of physiology · 2006Review
- An intersubunit zinc binding site in rat P2X2 receptors.The Journal of biological chemistry · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
1. The ATP receptor subunit P2X2 was expressed in Xenopus oocytes and human embryonic kidney (HEK) 293 cells. ATP-activated currents were studied with two-electrode voltage clamp recordings from oocytes, whole-cell recordings from HEK 293 cells, and outside-out patch clamp recordings from both cell types. The steady-state current-voltage (I-V) relation showed profound inward rectification in all recording configurations. 2. Recordings from outside-out patches demonstrated that inward rectification does not require intracellular Mg2+ or polyamines, and that inward rectification was present when the same solution was used on both sides of the patch. 3. Voltage jump experiments were performed to evaluate the voltage dependence of channel gating. After fast voltage jumps, instantaneous current jumps were followed by substantial relaxations to the steady state. The time course of the current relaxations could be fitted by single exponential functions. The instantaneous I-V relation was less inwardly rectifying than the steady-state I-V relation; however, it was not linear. 4. Single channel recordings indicated that the single channel conductance became smaller when the membrane potential became more positive. This decrease could quantitatively account for inward rectification of the instantaneous I-V relation. 5. We conclude that inward rectification of P2X2 is due to two mechanisms: voltage-dependent gating and voltage dependence of the single channel conductance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.