Trial reportBritish journal of clinical pharmacology1998
Comparison of the effects of nadolol and bisoprolol on noradrenaline-evoked venoconstriction in man in vivo.
Trial report in British journal of clinical pharmacology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 2 citations in OpenAlex.
- Trial
- Comparison of the effects of nadolol and bisoprolol on the isoprenaline-evoked dilatation of the dorsal hand vein in man.British journal of clinical pharmacology · 2001Trial
- Comparison of the effects of nadolol and bisoprolol on noradrenaline-evoked venoconstriction in man in vivo.British journal of clinical pharmacology · 1998Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsIn an attempt to explore the possible involvement of venodilator beta-adrenoceptors in the constrictor response of the human dorsal hand vein to noradrenaline, we examined the ability of nadolol, a non-selective beta1/beta2-adrenoceptor antagonist, and bisoprolol a selective beta1-adrenoceptor antagonist, to potentiate the response.
methodsTwelve healthy male volunteers participated in three weekly sessions. In each session nadolol (40 mg), bisoprolol (5 mg) or placebo was ingested, and (-) noradrenaline acid tartrate (0.33-33.33 ng min ) was infused locally into the dorsal hand vein 2 h after the ingestion of the drugs. Changes in vein diameter were monitored with the dorsal hand vein compliance technique. Subjects were allocated to treatments and sessions according to a double-blind balanced cross-over design. Systolic and diastolic blood pressure, and heart rate were also measured.
resultsNoradrenaline produced dose-dependent venoconstriction which was antagonized by bisoprolol but remained unaffected by nadolol (ANOVA with repeated measures: F(2,22) = 5.07, P < 0.025; Dunnett's test: placebo vs nadolol; t = 0.35, df = 22, k = 3, NS; placebo vs bisoprolol; t = 2.83, df = 22, k = 3, P < 0.01). Mean (+/- s.e. mean) logED50s (ng min[-1]) were 0.44 +/- 0.15 (placebo), 0.73 +/- 0.11 (bisoprolol) and 0.50 +/- 0.21 (nadolol); mean (95% CI) differences were 0.29 (-0.005, 0.58) for placebo vs bisoprolol and 0.06 (-0.35, 0.46) for placebo vs nadolol. Both active drugs significantly (compared with placebo, P < 0.05) decreased (mean change from pretreatment +/- s.e. mean) heart rate (bisoprolol -16.08 +/- 2.01; nadolol -11.67 +/- 2.06) and systolic blood pressure (bisoprolol -15.0 +/- 0.80; nadolol -9.47 +/- 0.18).
conclusionsThe failure of nadolol and bisoprolol to potentiate noradrenaline-evoked venoconstriction argues against the involvement of masked venodilator beta-adrenoceptors in the response. The mechanism underlying the antagonism of noradrenaline-evoked venoconstriction by bisoprolol remains to be elucidated.
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