ArticleClinical & experimental metastasis1998
Heterogeneous suppression of experimentally induced colon cancer metastasis in rat liver lobes by inhibition of extracellular cathepsin B.
Article in Clinical & experimental metastasis, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 70 citations in OpenAlex.
- Article
- Optical imaging with a novel cathepsin-activatable probe for enhanced detection of colorectal cancer.American journal of nuclear medicine and molecular imaging · 2019Article
- Reduction of proteinuria through podocyte alkalinization.The Journal of biological chemistry · 2014Article
- Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B.International journal of cancer · 2012Article
- Activatable Optical Probes for the Detection of Enzymes.Current organic synthesis · 2011Article
- Imaging enzymes at work: metabolic mapping by enzyme histochemistry.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Review
- Is there a genetic signature for liver metastasis in colorectal cancer?World journal of gastroenterology · 2007Review
- Lysosomal destabilization contributes to apoptosis of germinal center B-lymphocytes.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2006Article
- Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells.Journal of cancer research and clinical oncology · 2006Article
- Late stage inhibition of hematogenous melanoma metastasis by cystatin C over-expression.Cancer cell international · 2005Article
- Extracellular matrix degrading enzymes at the prostasome surface.Prostate cancer and prostatic diseases · 2005Article
- Structural examination of tryptase- and chymase-positive mast cells in livers, containing metastases from gastrointestinal cancers.Clinical & experimental metastasis · 2003Article
- The metastatic potential of human pancreatic cell lines in the liver of nude mice correlates well with cathepsin B activity.International journal of gastrointestinal cancer · 2003Article
- Tenascin immunoreactivity in the large bowel and the liver in patients with colorectal cancer.The Histochemical journal · 2001Article
- Ito cell morphology, alpha-smooth muscle actin and collagen type IV expression in the liver of patients with gastric and colorectal tumors.The Histochemical journal · 2000Article
- In vivo inhibition of cysteine proteinases delays the onset of growth of human pancreatic cancer explants.British journal of cancer · 2000Article
- Promotion of colon cancer metastases in rat liver by fish oil diet is not due to reduced stroma formation.Clinical & experimental metastasis · 2000Article
- In vivo treatment of rats with unfractionated heparin (UFH) or low molecular weight heparin (LMWH) does not affect experimentally induced colon carcinoma metastasis.Clinical & experimental metastasis · 1999Article
- Expression of cell adhesion molecules, their ligands and tumour necrosis factor alpha in the liver of patients with metastatic gastrointestinal carcinomas.The Histochemical journalArticle
- Imaging proteolysis by living human breast cancer cells.Neoplasia (New York, N.Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metastatic rat colon cancer cells but not normal rat hepatocytes showed activity of cathepsin B on their plasma membranes. Activity was visualized in living cells with a new fluorogenic substrate, [Z-Arg]2-cresyl violet, and confocal microscopy. When these cancer cells were injected into the portal vein of rats, the animals developed tumors in the liver in a heterogeneous fashion. Three- to four-fold more tumors were found in the small caudate lobe than in the other three large lobes of the liver. Oral treatment with a selective water-soluble inhibitor of extracellular cathepsin B, Mu-Phe-homoPhe-fluoromethylketone, resulted in 60% reduction of the number of tumors and 80% reduction of the volume of tumors in the three large lobes whereas tumor development was not affected in the small caudate lobe. This study supports the conclusions that (a) extracellular cathepsin B plays a crucial but complex role in liver colonisation by rat colon carcinoma cells in vivo, (b) its selective inhibition suppresses tumor growth heterogeneously in the liver and (c) the caudate lobe of the liver is a relatively large risk factor for tumor development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.