ArticleGenes & development1998
Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway.
Article in Genes & development, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 73 citations in OpenAlex.
- The Non-receptor Tyrosine Kinase Pyk2 in Brain Function and Neurological and Psychiatric Diseases.Frontiers in synaptic neuroscience · 2021Review
- Dihydropyridine Calcium Channel Blockers Suppress the Transcription of PD-L1 by Inhibiting the Activation of STAT1.Frontiers in pharmacology · 2020Article
- Interleukin-2 (IL-2) Interacts With IL-2 Receptor Beta (IL-2Rβ): Its Potential to Enhance the Proliferation of CD4+ T Lymphocytes in Flounder (Frontiers in immunology · 2020Article
- The Mechanistic Differences in HLA-Associated Carbamazepine Hypersensitivity.Pharmaceutics · 2019Article
- Article
- PYK2 integrates growth factor and cytokine receptors signaling and potentiates breast cancer invasion via a positive feedback loop.Oncotarget · 2015Article
- Functions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement.Immunologic research · 2014Review
- Transcriptome-wide RNA interaction profiling reveals physical and functional targets of hnRNP L in human T cells.Molecular and cellular biology · 2014Article
- Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia.PLoS genetics · 2013Article
- Cross-regulation of signaling by ITAM-associated receptors.Nature immunology · 2009Review
- Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes.Arthritis and rheumatism · 2009Article
- LPS-induced MCP-1 expression in human microvascular endothelial cells is mediated by the tyrosine kinase, Pyk2 via the p38 MAPK/NF-kappaB-dependent pathway.Molecular immunology · 2009Article
- The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction.Biochemical and biophysical research communications · 2007Article
- Inhibition of nitric oxide synthase and farnesyltransferase change the activities of several transcription factors.Journal of molecular neuroscience : MN · 2007Article
- Focal adhesion kinase-related protein tyrosine kinase Pyk2 in T-cell activation and function.Immunologic research · 2005Review
- Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Article
- Review
- Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling.The EMBO journal · 1999Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many cytokines transmit signals to the cell interior through activation of receptor-associated, Janus family protein tyrosine kinases (Jak PTKs). The interleukin-2 receptor (IL-2R) is associated with the Jak1 and Jak3 PTKs, and ligand-induced activation of these PTKs is essential for lymphocyte proliferation. Here, the nonreceptor PTK, Pyk2, was found to be activated following IL-2 stimulation in a Jak-dependent manner. Furthermore, physical association was detected between endogenous Pyk2 and Jak3, and a dominant interfering mutant of Pyk2 inhibited IL-2-induced cell proliferation without affecting Stat5 activation. Collectively, these results suggest that Pyk2 is a newly identified component of the Jak-mediated IL-2 signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.