ArticleThe Biochemical journal1998
Functional expression of TrpC1: a human homologue of the Drosophila Trp channel.
Article in The Biochemical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 109 citations in OpenAlex.
- Effects of microgravity mechanotransduction in bone tissue and cells: systematic review on primary cilium-dependent mechanisms.NPJ microgravity · 2026Article
- Transient receptor potential canonical 3/5 attenuate endothelial damage-induced neointima formation without affecting endothelial cell proliferation.European journal of histochemistry : EJH · 2025Article
- ORAI1 CaFrontiers in cell and developmental biology · 2021Review
- TRPC1 as a negative regulator for TRPC4 and TRPC5 channels.Pflugers Archiv : European journal of physiology · 2019Review
- Store-Operated Calcium Entry in Müller Glia Is Controlled by Synergistic Activation of TRPC and Orai Channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Permeation, regulation and control of expression of TRP channels by trace metal ions.Pflugers Archiv : European journal of physiology · 2015Review
- Isoform- and receptor-specific channel property of canonical transient receptor potential (TRPC)1/4 channels.Pflugers Archiv : European journal of physiology · 2014Article
- Mechanism and functional significance of TRPC channel multimerization.Seminars in cell & developmental biology · 2006Review
- Molecular and electrophysiological characterization of transient receptor potential ion channels in the primary murine megakaryocyte.The Journal of physiology · 2006Article
- TRPC3 properties of a native constitutively active Ca2+-permeable cation channel in rabbit ear artery myocytes.The Journal of physiology · 2006Article
- A role for 5,6-epoxyeicosatrienoic acid in calcium entry by de novo conformational coupling in human platelets.The Journal of physiology · 2006Article
- Physiological mechanisms of TRPC activation.Pflugers Archiv : European journal of physiology · 2005Review
- Na(+) entry and modulation of Na(+)/Ca(2+) exchange as a key mechanism of TRPC signaling.Pflugers Archiv : European journal of physiology · 2005Review
- TRP channels in airway smooth muscle as therapeutic targets.Naunyn-Schmiedeberg's archives of pharmacology · 2005Review
- TRPC3: a versatile transducer molecule that serves integration and diversification of cellular signals.Naunyn-Schmiedeberg's archives of pharmacology · 2005Review
- Evidence that TRPC1 (transient receptor potential canonical 1) forms a Ca(2+)-permeable channel linked to the regulation of cell volume in liver cells obtained using small interfering RNA targeted against TRPC1.The Biochemical journal · 2003Article
- Pharmacological profile of store-operated channels in cerebral arteriolar smooth muscle cells.British journal of pharmacology · 2003Article
- Discrete store-operated calcium influx into an intracellular compartment in rabbit arteriolar smooth muscle.The Journal of physiology · 2002Article
- Specific detection of the endogenous transient receptor potential (TRP)-1 protein in liver and airway smooth muscle cells using immunoprecipitation and Western-blot analysis.The Biochemical journal · 2002Article
- Increased inwardly rectifying potassium currents in HEK-293 cells expressing murine transient receptor potential 4.The Biochemical journal · 2001Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
TrpC1 appears to be a store-operated channel (SOC) when expressed in mammalian cells. In the present study, TrpC1 was expressed in Sf9 insect cells using the baculovirus expression system. Expression of TrpC1 caused an increase in basal cytosolic free Ca2+ concentration ([Ca2+]i) as a function of post-infection time. Basal Ba2+ influx, an index of plasmalemmal Ca2+ permeability, was also increased and was blocked by La3+. Although the thapsigargin-induced change in [Ca2+]i was greater in TrpC1-expressing cells than controls, Ba2+ influx was unaffected by thapsigargin. Whole-cell membrane currents recorded in TrpC1-expressing cells increased as a function of post-infection time and were (1) inwardly rectifying in symmetrical sodium gluconate solutions, (2) non-selective with respect to Na+, Ca2+ and Ba2+, and (3) blocked by La3+. Furthermore TrpC1 currents were unaffected by (1) thapsigargin, (2) dialysis of the cell with Ins(1,4,5)P3 or (3) dialysis of the cell with solutions containing high concentrations of the Ca2+ chelator, EGTA. These results suggest that TrpC1 forms non-selective cation channels that are constitutively active when expressed in Sf9 cells, but insensitive to depletion of the internal Ca2+ stores. Thus TrpC1 may be a subunit of a SOC which alone can form functional channels in Sf9 cells, but which requires additional subunits or cytoplasmic factors present in mammalian cells for expression of SOC activity.
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