ArticleBiophysical journal1998
Mitochondrial calcium in relaxed and tetanized myocardium.
Article in Biophysical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Interplay of mitochondrial calcium signalling and reactive oxygen species production in the brain.Biochemical Society transactions · 2024Review
- Review
- Tight mitochondrial control of calcium and exocytotic signals in chromaffin cells at embryonic life.Pflugers Archiv : European journal of physiology · 2015Article
- The mitochondrial calcium uniporter: mice can live and die without it.Journal of molecular and cellular cardiology · 2015Review
- Calcium movement in cardiac mitochondria.Biophysical journal · 2014Article
- Calcium signaling in cardiac mitochondria.Journal of molecular and cellular cardiology · 2013Review
- Mitochondria and chromaffin cell function.Pflugers Archiv : European journal of physiology · 2012Review
- Calcium-dependent mitochondrial function and dysfunction in neurons.The FEBS journal · 2010Review
- Mitochondrial free calcium regulation during sarcoplasmic reticulum calcium release in rat cardiac myocytes.Journal of molecular and cellular cardiology · 2009Article
- Mitochondrial Ca2+ uptake: tortoise or hare?Journal of molecular and cellular cardiology · 2009Article
- Microheterogeneity of calcium signalling in dendrites.The Journal of physiology · 2000Review
- Quantitative analysis of mitochondrial Ca2+ uptake and release pathways in sympathetic neurons. Reconstruction of the recovery after depolarization-evoked [Ca2+]i elevations.The Journal of general physiology · 2000Article
- Depolarization-induced mitochondrial Ca accumulation in sympathetic neurons: spatial and temporal characteristics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Twitch-potentiation increases calcium in peripheral more than in central mitochondria of guinea-pig ventricular myocytes.The Journal of physiology · 1999Article
- The role of nitric oxide in abnormal T cell signal transduction in systemic lupus erythematosus.Clinical immunology (Orlando, Fla.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The elemental composition of rat cardiac muscle was determined with electron probe x-ray microanalysis (EPMA) of rapidly frozen papillary muscles and trabeculae incubated with ryanodine (1 microM) in either 1.2 or 10 mM [Ca2+]o-containing solutions, paced at 0.6 Hz or tetanized at 10 Hz. Total mitochondrial calcium increased significantly, by 4.2 mmol/kg dry weight during a 7 s tetanus, only in muscles tetanized in the presence of 10 mM [Ca2+]o when cytoplasmic Ca2+ is 1-4 microM (Backx, P. H., W.-D. Gao, M. D. Azan-Backx, and E. Marban. 1995. The relationship between contractile force and intracellular [Ca2+] in intact rat trabeculae. J. Gen. Physiol. 105:1-19). Comparison of total mitochondrial with free mitochondrial Ca2+ reported in the literature indicates that the total/free ratio is approximately 6000 at physiological or near-physiological levels of total mitochondrial calcium. Increases in free mitochondrial [Ca2+] consistent with regulation of mitochondrial enzymes should be associated with increases in total mitochondrial calcium detectable with EPMA. However, such increases in mitochondrial calcium occur only as the result of prolonged, unphysiological elevations of cytosolic [Ca2+].
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