ArticleBiophysical journal1998
Functional co-assembly among subunits of cyclic-nucleotide-activated, nonselective cation channels, and across species from nematode to human.
Article in Biophysical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Modulation of the NO-cGMP pathway has no effect on olfactory responses in theFrontiers in cellular neuroscience · 2023Article
- Chemical shift assignments of calmodulin bound to a C-terminal site (residues 1120-1147) in the β-subunit of a retinal cyclic nucleotide-gated channel (CNGB1).Biomolecular NMR assignments · 2022Article
- Chemical shift assignments of calmodulin bound to the β-subunit of a retinal cyclic nucleotide-gated channel (CNGB1).Biomolecular NMR assignments · 2022Article
- A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation.Science advances · 2020Article
- The cone dysfunction syndromes.The British journal of ophthalmology · 2016Review
- Article
- The cone dysfunction syndromes.The British journal of ophthalmology · 2004Review
- Expression of olfactory-type cyclic nucleotide-gated channel (CNGA2) in vascular tissues.Histochemistry and cell biology · 2003Article
- Subunit contributions to phosphorylation-dependent modulation of bovine rod cyclic nucleotide-gated channels.The Journal of physiology · 2003Article
- Mechanism of calcium/calmodulin inhibition of rod cyclic nucleotide-gated channels.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- The vitelliform macular dystrophy protein defines a new family of chloride channels.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Efficient coupling of ligand binding to channel opening by the binding domain of a modulatory (beta) subunit of the olfactory cyclic nucleotide-gated channel.The Journal of general physiology · 2001Article
- Interactions of cyclic nucleotide-gated channel subunits and protein tyrosine kinase probed with genistein.The Journal of general physiology · 2000Article
- Structural basis for ligand selectivity of heteromeric olfactory cyclic nucleotide-gated channels.Biophysical journal · 2000Article
- Ca2+ permeation in cyclic nucleotide-gated channels.The EMBO journal · 1999Article
- Stoichiometry and arrangement of heteromeric olfactory cyclic nucleotide-gated ion channels.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Cyclic-nucleotide-activated, nonselective cation channels have a central role in sensory transduction. They are most likely tetramers, composed of two subunits (alpha and beta or 1 and 2), with the former, but not the latter, being able to form homomeric cyclic-nucleotide-activated channels. Identified members of this channel family now include, in vertebrates, the rod and cone channels mediating visual transduction and the channel mediating olfactory transduction, each apparently with distinct alpha- and beta-subunits. Homologous channels have also been identified in Drosophila melanogaster and Caenorhabditis elegans. By co-expressing any combination of two alpha-subunits, or alpha- and beta-subunits, of this channel family in HEK 293 cells, we have found that they can all co-assemble functionally with each other, including those from fly and nematode. This finding suggests that the subunit members so far identified form a remarkably homogeneous and conserved group, functionally and evolutionarily, with no subfamilies yet identified. The ability to cross-assemble allows these subunits to potentially generate a diversity of heteromeric channels, each with properties specifically suited to a particular cellular function.
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