ArticleBiophysical journal1998
Theory for ligand rebinding at cell membrane surfaces.
Article in Biophysical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- The interaction of a self-assembled nanoparticle and a lipid membrane: Binding, disassembly and re-distribution.Heliyon · 2024Article
- Location, location, location: Protein kinase nanoclustering for optimised signalling output.eLife · 2024Review
- pSpatiocyte: a high-performance simulator for intracellular reaction-diffusion systems.BMC bioinformatics · 2020Article
- Using the novel HiBiT tag to label cell surface relaxin receptors for BRET proximity analysis.Pharmacology research & perspectives · 2019Article
- Receptor-Ligand Rebinding Kinetics in Confinement.Biophysical journal · 2019Article
- Continuous biomarker monitoring by particle mobility sensing with single molecule resolution.Nature communications · 2018Article
- Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine DNature communications · 2017Article
- Caulobacter PopZ forms an intrinsically disordered hub in organizing bacterial cell poles.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
- Design of growth factor sequestering biomaterials.Chemical communications (Cambridge, England) · 2014Review
- Nanoclustering as a dominant feature of plasma membrane organization.Journal of cell science · 2014Review
- A general mechanism for competitor-induced dissociation of molecular complexes.Nature communications · 2014Article
- PTEN hopping on the cell membrane is regulated via a positively-charged C2 domain.PLoS computational biology · 2014Article
- Serum-dependence of affinity-mediated VEGF release from biomimetic microspheres.Biomacromolecules · 2014Article
- Fast rebinding increases dwell time of Src homology 2 (SH2)-containing proteins near the plasma membrane.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Proteolytic activity at quantum dot-conjugates: kinetic analysis reveals enhanced enzyme activity and localized interfacial "hopping".Nano letters · 2012Article
- Measuring surface binding thermodynamics and kinetics by using total internal reflection with fluorescence correlation spectroscopy: practical considerations.The journal of physical chemistry. B · 2011Article
- The role of receptor interactions in regulating ethylene signal transduction.Plant signaling & behavior · 2009Article
- Single-molecule fluorescence studies of a PH domain: new insights into the membrane docking reaction.Biophysical journal · 2009Article
- A catalytic role of heparin within the extracellular matrix.The Journal of biological chemistry · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Conditions for which a ligand reversibly bound to a cell surface dissociates and then rebinds to the surface have been theoretically examined. The coupled differential equations that describe reaction at the interface between sites on a plane and three-dimensional solution have been described previously (Thompson, N. L., T. P. Burghardt, and D. Axelrod. 1981. Biophys. J. 33:435-454). Here, we use this theoretical formalism to provide an analytical solution for the spatial and temporal dependence of the probabilities of finding a molecule on the surface or in the solution, given initial placement on the surface at the origin. This general analytical solution is used to derive a simple expression for the probability that a molecule rebinds to the surface at a given position and time after release at the origin and time zero. The probability expressions provide fundamental equations that form a basis for subsequent modeling of ligand-receptor interactions in specific geometries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.