ArticleJapanese journal of cancer research : Gann1998
A large germline deletion of the MEN1 gene in a family with multiple endocrine neoplasia type 1.
Article in Japanese journal of cancer research : Gann, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 67 citations in OpenAlex.
- Article
- Deletion of exons 1-3 of the MEN1 gene in a large Italian family causes the loss of menin expression.Familial cancer · 2014Article
- Copy number variations and cancer.Genome medicine · 2009Article
- MEN1 gene and its mutations: basic and clinical implications.Cancer science · 2009Review
- Article
- Clinical and genetic features of patients with multiple endocrine tumors who have neither family history nor MEN1 germline mutations.Endocrine · 2004Article
- The MEN1 gene and associated diseases: an update.Endocrine pathology · 2001Review
- Identification of MEN1 gene mutations in families with MEN 1 and related disorders.British journal of cancer · 2000Article
- Characterization of the MEN1 gene product, menin, by site-specific polyclonal antibodies.Japanese journal of cancer research : Gann · 1999Article
- Germ-line mutation analysis in patients with multiple endocrine neoplasia type 1 and related disorders.American journal of human genetics · 1998Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple endocrine neoplasia type 1 (MEN1) is a familial cancer syndrome inherited as an autosomal dominant trait. Various heterozygous germline mutations of the responsible gene, MEN1, have been identified within its exons in many, but not all, affected individuals. We here demonstrate, by DNA polymorphism analysis and gene dosage analysis with polymerase chain reaction (PCR), a large heterozygous germline MEN1 deletion in a kindred with MEN1, in whom no mutation could be detected in the PCR-amplified exons. The deletion spanned an at least 7 kb region containing the entire MEN1 gene. These findings indicate that a large germline deletion of the MEN1 gene, which escapes detection in PCR-based sequence analysis, should be considered as a potential cause of MEN1.
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