ArticleThe Journal of cell biology1998
The coordination of centrosome reproduction with nuclear events of the cell cycle in the sea urchin zygote.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 86 citations in OpenAlex.
- Centriolar satellites regulateMolecular biology of the cell · 2026Article
- Centriolar satellites regulatebioRxiv : the preprint server for biology · 2026Article
- Manipulating cultured mammalian cells for mitosis research.Methods in cell biology · 2020Article
- SUMOylation regulates the localization and activity of Polo-like kinase 1 during cell cycle in the silkworm, Bombyx mori.Scientific reports · 2017Article
- Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay.Nature communications · 2017Article
- Review
- Dynein light intermediate chains maintain spindle bipolarity by functioning in centriole cohesion.The Journal of cell biology · 2014Article
- Liver kinase B1 regulates the centrosome via PLK1.Cell death & disease · 2014Article
- Show me your license, please: deregulation of centriole duplication mechanisms that promote amplification.Cellular and molecular life sciences : CMLS · 2013Review
- Such small hands: the roles of centrins/caltractins in the centriole and in genome maintenance.Cellular and molecular life sciences : CMLS · 2012Review
- Centrosome biogenesis continues in the absence of microtubules during prolonged S-phase arrest.Journal of cellular physiology · 2010Article
- Kinesins to the core: The role of microtubule-based motor proteins in building the mitotic spindle midzone.Seminars in cell & developmental biology · 2010Review
- The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication.The Journal of cell biology · 2009Article
- Cyclin E in centrosome duplication and reduplication in sea urchin zygotes.Journal of cellular physiology · 2008Article
- Intrinsic and cyclin-dependent kinase-dependent control of spindle pole body duplication in budding yeast.Molecular biology of the cell · 2008Article
- Centrosome duplication proceeds during mimosine-induced G1 cell cycle arrest.Journal of cellular physiology · 2008Article
- Bisphenol A directly targets tubulin to disrupt spindle organization in embryonic and somatic cells.ACS chemical biology · 2008Article
- Mitotic cell death in BEL-7402 cells induced by enediyne antibiotic lidamycin is associated with centrosome overduplication.World journal of gastroenterology · 2004Article
- Centrosomes split in the presence of impaired DNA integrity during mitosis.Molecular biology of the cell · 2003Article
- Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase.Current biology : CB · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Centrosomes repeatedly reproduce in sea urchin zygotes arrested in S phase, whether cyclin-dependent kinase 1-cyclin B (Cdk1-B) activity remains at prefertilization levels or rises to mitotic values. In contrast, when zygotes are arrested in mitosis using cyclin B Delta-90, anaphase occurs at the normal time, yet centrosomes do not reproduce. Together, these results reveal the cell cycle stage specificity for centrosome reproduction and demonstrate that neither the level nor the cycling of Cdk1-B activity coordinate centrosome reproduction with nuclear events. In addition, the proteolytic events of the metaphase-anaphase transition do not control when centrosomes duplicate. When we block protein synthesis at first prophase, the zygotes divide and arrest before second S phase. Both blastomeres contain just two complete centrosomes, which indicates that the cytoplasmic conditions between mitosis and S phase support centrosome reproduction. However, the fact that these daughter centrosomes do not reproduce again under such supportive conditions suggests that they are lacking a component required for reproduction. The repeated reproduction of centrosomes during S phase arrest points to the existence of a necessary "licensing" event that restores this component to daughter centrosomes during S phase, preparing them to reproduce in the next cell cycle.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.