ArticleGenetics1998
Meta-analysis of linkage data under worst-case conditions: a demonstration using the human OB region.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Meta-analysis of genome-wide association from genomic prediction models.Animal genetics · 2016Pooled it
- Meta analysis of whole-genome linkage scans with data uncertainty: an application to Parkinson's disease.BMC genetics · 2007Pooled it
- Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia.Molecular psychiatry · 2002Pooled it
- Regional meta-analysis of published data supports linkage of autism with markers on chromosome 7.Molecular psychiatry · 2002Pooled it
- The association of insertions/deletions (INDELs) and variable number tandem repeats (VNTRs) with obesity and its related traits and complications.Journal of physiological anthropology · 2017Review
- Weight gain, schizophrenia and antipsychotics: new findings from animal model and pharmacogenomic studies.Schizophrenia research and treatment · 2011Article
- Combining two Meishan F2 crosses improves the detection of QTL on pig chromosomes 2, 4 and 6.Genetics, selection, evolution : GSE · 2010Article
- Data integration in genetics and genomics: methods and challenges.Human genomics and proteomics : HGP · 2009Article
- MetaQTL: a package of new computational methods for the meta-analysis of QTL mapping experiments.BMC bioinformatics · 2007Article
- An empirical Bayes method for updating inferences in analysis of quantitative trait loci using information from related genome scans.Genetics · 2006Article
- A male-specific quantitative trait locus on 1p21 controlling human stature.Journal of medical genetics · 2005Article
- The future of association studies: gene-based analysis and replication.American journal of human genetics · 2004Article
- Common variants in the 5' region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study.American journal of human genetics · 2004Article
- Searching for osteoporosis genes in the post-genome era: progress and challenges.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2003Review
- Meta-analysis of genetic-linkage analysis of quantitative-trait loci.American journal of human genetics · 2002Article
- A combined analysis of genomewide linkage scans for body mass index from the National Heart, Lung, and Blood Institute Family Blood Pressure Program.American journal of human genetics · 2002Article
- Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: the National Heart, Lung, and Blood Institute Family Heart Study.American journal of human genetics · 2002Article
- The significance of not finding a gene.American journal of human genetics · 2001Article
- Incorporation of molecular data and redefinition of phenotype: new approaches to genetic epidemiology of bipolar manic depressive illness and schizophrenia.Dialogues in clinical neuroscience · 2001Article
- Combined analyses of data from quantitative trait loci mapping studies. Chromosome 4 effects on porcine growth and fatness.Genetics · 2000Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
To date, few methods have been developed explicitly for meta-analysis of linkage analyses. Moreover, the methods that have been developed or suggested generally depend on certain ideal situations and have not been widely applied. In this article, we apply standard statistical theory and meta-analytic techniques in novel ways to five published papers discussing the evidence of linkage of body mass index (BMI) to the region of the human genome containing the OB gene. These methods are "inference based," meaning that they allow one to make statements about the statistical significance of the entire body of evidence. As currently developed, they do not allow specific statements to be made about the amount of variance explained by any putative locus or allow precise confidence intervals to be placed around the putative location of a linked locus. By applying these techniques to the literature on linkage in the human OB gene region, we are able to show that the evidence for linkage somewhere in the region is extremely strong (P = 1.5 x 10[-5]).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.