ArticleGenetics1998
Comparative analysis of position-effect variegation mutations in Drosophila melanogaster delineates the targets of modifiers.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Sequence, Chromatin and Evolution of Satellite DNA.International journal of molecular sciences · 2021Review
- A massively parallel reporter assay dissects the influence of chromatin structure on cis-regulatory activity.Nature biotechnology · 2018Article
- Wash interacts with lamin and affects global nuclear organization.Current biology : CB · 2015Article
- Perturbation analysis of heterochromatin-mediated gene silencing and somatic inheritance.PLoS genetics · 2010Article
- The XNP remodeler targets dynamic chromatin in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Article
- Transcriptional adaptor ADA3 of Drosophila melanogaster is required for histone modification, position effect variegation, and transcription.Molecular and cellular biology · 2008Article
- Article
- A Drosophila homologue of Sir2 modifies position-effect variegation but does not affect life span.Genetics · 2002Article
- Modifiers of terminal deficiency-associated position effect variegation in Drosophila.Genetics · 2002Article
- Article
- mediator of paramutation1 is required for establishment and maintenance of paramutation at multiple maize loci.The Plant cell · 2000Article
- Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster.Genetics · 2000Article
- Changes in chromosomal localization of heterochromatin-binding proteins during the cell cycle in Drosophila.The Journal of cell biology · 1998Article
- Heterochromatin-mediated gene silencing is not affected by Drosophila CBP activity.The Journal of heredityArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila melanogaster, heterochromatin-induced silencing or position-effect variegation (PEV) of a reporter gene has provided insights into the properties of heterochromatin. Class I modifiers suppress PEV, and class II modifiers enhance PEV when the modifier gene is present in fewer than two doses. We have examined the effects of both class I and class II modifiers on four PEV mutations. These mutations include the inversions In(1)w(m4) and In(2R)bw(VDe2), which are classical chromosomal rearrangements that typify PEV mutations. The other mutations are a derivative of brown(Dominant), in which brown+ reporters are inactivated by a large block of heterochromatin, and a P[white+] transposon insertion associated with second chromosome heterochromatin. In general, we find that class I modifiers affect both classical and nonclassical PEV mutations, whereas class II modifiers affect only classical PEV mutations. We suggest that class II modifiers affect chromatin architecture in the vicinity of reporter genes, and only class I modifiers identify proteins that are potentially involved in heterochromatin formation or maintenance. In addition, our observations support a model in which there are different constraints on the process of heterochromatin-induced silencing in classical vs. nonclassical PEV mutations.
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