ArticleGenetics1998
hyp loci control cell pattern formation in the vegetative mycelium of Aspergillus nidulans.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 76 citations in OpenAlex.
- Establishing an Efficient Genetic Manipulation System for Sulfated Echinocandin Producing FungusFrontiers in microbiology · 2021Article
- Article
- Small Molecular Contaminant and Microorganism Can Be Simultaneously Detected Based on Nanobody-Phage: Using Carcinogen Aflatoxin and Its Main FungalFrontiers in microbiology · 2019Article
- Internuclear diffusion of histone H1 within cellular compartments of Aspergillus nidulans.PloS one · 2018Article
- GBF/Gea mutant with a single substitution sustains fungal growth in the absence of BIG/Sec7.FEBS letters · 2014Article
- Characterization of the mutagenic spectrum of 4-nitroquinoline 1-oxide (4-NQO) in Aspergillus nidulans by whole genome sequencing.G3 (Bethesda, Md.) · 2014Article
- Mitotic regulation of fungal cell-to-cell connectivity through septal pores involves the NIMA kinase.Molecular biology of the cell · 2014Article
- Quantifying the importance of galactofuranose in Aspergillus nidulans hyphal wall surface organization by atomic force microscopy.Eukaryotic cell · 2011Article
- The effect of temperature on Natural Antisense Transcript (NAT) expression in Aspergillus flavus.Current genetics · 2008Article
- Comparison between polyethylene glycol- and polyethylenimine-mediated transformation of Aspergillus nidulans.Current genetics · 2008Article
- Impaired ribosome biogenesis disrupts the integration between morphogenesis and nuclear duplication during the germination of Aspergillus fumigatus.Eukaryotic cell · 2008Article
- Depletion of Aspergillus nidulans cotA causes a severe polarity defect which is not suppressed by the nuclear migration mutation nudA2.Molecular genetics and genomics : MGG · 2006Article
- Polarisome meets spitzenkörper: microscopy, genetics, and genomics converge.Eukaryotic cell · 2005Review
- Depletion of a polo-like kinase in Candida albicans activates cyclase-dependent hyphal-like growth.Molecular biology of the cell · 2003Article
- Aspergillus nidulans septin AspB plays pre- and postmitotic roles in septum, branch, and conidiophore development.Molecular biology of the cell · 2002Article
- Quantitative PCR assay to measure Aspergillus fumigatus burden in a murine model of disseminated aspergillosis: demonstration of efficacy of caspofungin acetate.Antimicrobial agents and chemotherapy · 2001Article
- Accumulation of stress and inducer-dependent plant-cell-wall-degrading enzymes during asexual development in Aspergillus nidulans.Genetics · 2001Article
- Article
- Cell polarity and hyphal morphogenesis are controlled by multiple rho-protein modules in the filamentous ascomycete Ashbya gossypii.Genetics · 2001Article
- Extragenic suppressors of the nimX2(cdc2) mutation of Aspergillus nidulans affect nuclear division, septation and conidiation.Genetics · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Aspergillus nidulans grows by apical extension of multinucleate cells called hyphae that are subdivided by the insertion of crosswalls called septa. Apical cells vary in length and number of nuclei, whereas subapical cells are typically 40 microm long with three to four nuclei. Apical cells have active mitotic cycles, whereas subapical cells are arrested for growth and mitosis until branch formation reinitiates tip growth and nuclear divisions. This multicellular growth pattern requires coordination between localized growth, nuclear division, and septation. We searched a temperature-sensitive mutant collection for strains with conditional defects in growth patterning and identified six mutants (designated hyp for hypercellular). The identified hyp mutations are nonlethal, recessive defects in five unlinked genes (hypA-hypE). Phenotypic analyses showed that these hyp mutants have aberrant patterns of septation and show defects in polarity establishment and tip growth, but they have normal nuclear division cycles and can complete the asexual growth cycle at restrictive temperature. Temperature shift analysis revealed that hypD and hypE play general roles in hyphal morphogenesis, since inactivation of these genes resulted in a general widening of apical and subapical cells. Interestingly, loss of hypA or hypB function lead to a cessation of apical cell growth but activated isotropic growth and mitosis in subapical cells. The inferred functions of hypA and hypB suggest a mechanism for coordinating apical growth, subapical cell arrest, and mitosis in A. nidulans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.