ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
dSLo interacting protein 1, a novel protein that interacts with large-conductance calcium-activated potassium channels.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 68 citations in OpenAlex.
- HRPU-2, a Homolog of Mammalian hnRNP U, Regulates Synaptic Transmission by Controlling the Expression of SLO-2 Potassium Channel inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- MaxiK channel interactome reveals its interaction with GABA transporter 3 and heat shock protein 60 in the mammalian brain.Neuroscience · 2016Article
- An unexpected journey: conceptual evolution of mechanoregulated potassium transport in the distal nephron.American journal of physiology. Cell physiology · 2016Review
- A novel auxiliary subunit critical to BK channel function in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- α-Catulin CTN-1 is required for BK channel subcellular localization in C. elegans body-wall muscle cells.The EMBO journal · 2010Article
- Impaired function of coronary BK(Ca) channels in metabolic syndrome.American journal of physiology. Heart and circulatory physiology · 2009Article
- Mechanoregulation of BK channel activity in the mammalian cortical collecting duct: role of protein kinases A and C.American journal of physiology. Renal physiology · 2009Article
- Regulation of colonic apical potassium (BK) channels by cAMP and somatostatin.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Use of optical biosensors to detect modulation of Slack potassium channels by G protein-coupled receptors.Journal of receptor and signal transduction research · 2009Article
- Alternatively spliced C-terminal domains regulate the surface expression of large conductance calcium-activated potassium channels.Neuroscience · 2007Article
- Mechanisms of two modulatory actions of the channel-binding protein Slob on the Drosophila Slowpoke calcium-dependent potassium channel.The Journal of general physiology · 2006Article
- MaxiK channel partners: physiological impact.The Journal of physiology · 2006Review
- Ca2+-independent activation of BKCa channels at negative potentials in mammalian inner hair cells.The Journal of physiology · 2005Article
- The amino terminus of Slob, Slowpoke channel binding protein, critically influences its modulation of the channel.The Journal of general physiology · 2005Article
- Identification and functional characterization of ankyrin-repeat family protein ANKRA as a protein interacting with BKCa channel.Molecular biology of the cell · 2005Article
- Association of beta-catenin with the alpha-subunit of neuronal large-conductance Ca2+-activated K+ channels.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Conditional protein phosphorylation regulates BK channel activity in rat cerebellar Purkinje neurons.The Journal of physiology · 2003Article
- Inactivation of BK channels by the NH2 terminus of the beta2 auxiliary subunit: an essential role of a terminal peptide segment of three hydrophobic residues.The Journal of general physiology · 2003Article
- Glial cell line-derived neurotrophic factor and target-dependent regulation of large-conductance KCa channels in developing chick lumbar motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Modulation of Drosophila slowpoke calcium-dependent potassium channel activity by bound protein kinase a catalytic subunit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large-conductance calcium-activated potassium channels (BK channels) are activated by depolarized membrane potential and elevated levels of intracellular calcium. BK channel activity underlies the fast afterhyperpolarization that follows an action potential and attenuates neurotransmitter and hormone secretion. Using a modified two-hybrid approach, the interaction trap, we have identified a novel protein from Drosophila, dSLIP1 (dSLo interacting protein), which specifically interacts with Drosophila and human BK channels and has partial homology to the PDZ domain of alpha1 syntrophin. The dSLIP1 and dSlo mRNAs are expressed coincidently throughout the Drosophila nervous system, the two proteins interact in vitro, and they may be coimmunoprecipitated from transfected cells. Coexpression of dSLIP1 with dSlo or hSlo BK channels in Xenopus oocytes results in reduced currents as compared with expression of BK channels alone; current amplitudes may be rescued by coexpression with the channel domain that interacts with dSLIP1. Single-channel recordings and immunostaining of transfected tissue culture cells suggest that dSLIP1 selectively reduces Slo BK currents by reducing the number of BK channels in the plasma membrane.
Indexed as
Identifiers
9502797PMC6793097W2146405466What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.