ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
A mutation affecting dihydropyridine-sensitive current levels and activation kinetics in Drosophila muscle and mammalian heart calcium channels.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
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- Biochemistry and physiology of voltage-gated calcium channel trafficking: a target for gabapentinoid drugs.Open biology · 2025Review
- Stac protein regulates release of neuropeptides.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Dstac Regulates Excitation-Contraction Coupling inFrontiers in physiology · 2020Article
- Suppression of myopathic lamin mutations by muscle-specific activation of AMPK and modulation of downstream signaling.Human molecular genetics · 2019Article
- Conservation of cardiac L-type CaJournal of molecular and cellular cardiology · 2018Article
- Dendritic and Axonal L-Type Calcium Channels Cooperate to Enhance Motoneuron Firing Output duringThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- Physiology and Evolution of Voltage-Gated Calcium Channels in Early Diverging Animal Phyla: Cnidaria, Placozoa, Porifera and Ctenophora.Frontiers in physiology · 2016Article
- Synaptic excitation is regulated by the postsynaptic dSK channel at the Drosophila larval NMJ.Journal of neurophysiology · 2014Article
- A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug.Disease models & mechanisms · 2011Article
- Orchestration of stepwise synaptic growth by K+ and Ca2+ channels in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Alternative splicing modulates diltiazem sensitivity of cardiac and vascular smooth muscle Ca(v)1.2 calcium channels.British journal of pharmacology · 2010Article
- Excitation-contraction coupling in skeletal muscle fibers from adult domestic honeybee.Pflugers Archiv : European journal of physiology · 2009Article
- Characterization of voltage-dependent Ca2+ currents in identified Drosophila motoneurons in situ.Journal of neurophysiology · 2008Article
- straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit.The Journal of cell biology · 2008Article
- Mutations in a Drosophila alpha2delta voltage-gated calcium channel subunit reveal a crucial synaptic function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Drosophila cacophony channels: a major mediator of neuronal Ca2+ currents and a trigger for K+ channel homeostatic regulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- CSTX-13, a highly synergistically acting two-chain neurotoxic enhancer in the venom of the spider Cupiennius salei (Ctenidae).Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- L-type Ca2+ channel and Ca2+-permeable nonselective cation channel as a Ca2+ conducting pathway in myocytes isolated from the cricket lateral oviduct.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2004Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The Dmca1D gene encodes a Drosophila calcium channel alpha1 subunit. We describe the first functional characterization of a mutation in this gene. This alpha1 subunit mediates the dihydropyridine-sensitive calcium channel current in larval muscle but does not contribute to the amiloride-sensitive current in that tissue. A mutation, which changes a highly conserved Cys to Tyr in transmembrane domain IS1, identifies a residue important for channel function not only in Drosophila muscle but also in mammalian cardiac channels. In both cases, mutations in this Cys residue slow channel activation and reduce expressed currents. Amino acid substitutions at this Cys position in the cardiac alpha1 subunit show that the size of the side chain, rather than its ability to form disulfide bonds, affects channel activation.
Indexed as
Identifiers
9502794PMC6793086W2151900378What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.