ArticleThe American journal of pathology1998
Focally regulated endothelial proliferation and cell death in human synovium.
Article in The American journal of pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 118 citations in OpenAlex.
- Emerging role of mesenchymal stem/stromal cells (MSCs) and MSCs-derived exosomes in bone- and joint-associated musculoskeletal disorders: a new frontier.European journal of medical research · 2023Review
- Synovitis in mice with inflammatory arthritis monitored with quantitative analysis of dynamic contrast-enhanced NIR fluorescence imaging using iRGD-targeted liposomes as fluorescence probes.International journal of nanomedicine · 2018Article
- Novel hyaluronic acid-methotrexate conjugate suppresses joint inflammation in the rat knee: efficacy and safety evaluation in two rat arthritis models.Arthritis research & therapy · 2016Article
- Calcitonin gene-related peptide in the joint: contributions to pain and inflammation.British journal of clinical pharmacology · 2015Review
- Anti-inflammatory effects of bamboo salt and sodium fluoride in human gingival fibroblasts--An in vitro study.The Kaohsiung journal of medical sciences · 2015Article
- Sinomenine decreases MyD88 expression and improves inflammation-induced joint damage progression and symptoms in rat adjuvant-induced arthritis.Inflammation · 2013Article
- Absorption, distribution, metabolism, and excretion (ADME) studies of biotherapeutics for autoimmune and inflammatory conditions.The AAPS journal · 2012Review
- Gene expression profiling and functional analysis of angiogenic markers in murine collagen-induced arthritis.Arthritis research & therapy · 2012Article
- Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis.Nature reviews. Rheumatology · 2012Review
- The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis.Nature reviews. Rheumatology · 2010Review
- Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis.Rheumatology (Oxford, England) · 2010Article
- Enhanced late-outgrowth circulating endothelial progenitor cell levels in rheumatoid arthritis and correlation with disease activity.Arthritis research & therapy · 2010Article
- Immature blood vessels in rheumatoid synovium are selectively depleted in response to anti-TNF therapy.PloS one · 2009Article
- The vasculature in rheumatoid arthritis: cause or consequence?International journal of experimental pathology · 2009Review
- Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis.Arthritis research & therapy · 2009Article
- Early lymphocyte activation in the synovial microenvironment in patients with osteoarthritis: comparison with rheumatoid arthritis patients and healthy controls.Rheumatology international · 2008Article
- Synovial proliferation differentially affects hypoxia in the joint cavities of rheumatoid arthritis and osteoarthritis patients.Clinical rheumatology · 2007Article
- Vascular endothelial growth factor (VEGF) in autoimmune diseases.Journal of clinical immunology · 2007Review
- Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition.Arthritis research & therapy · 2007Article
- Role of osteopontin in amplification and perpetuation of rheumatoid synovitis.The Journal of clinical investigation · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angiogenesis and vascular insufficiency each may support the chronic synovial inflammation of rheumatoid arthritis. We have shown by quantitative immunohistochemistry and terminal uridyl deoxynucleotide nick end labeling that endothelial proliferation and cell death indices were each increased in synovia from patients with rheumatoid arthritis compared with osteoarthritic and noninflamed controls, whereas endothelial fractional areas did not differ significantly among disease groups. Markers of proliferation were associated with foci immunoreactive for vascular endothelial growth factor and integrin alpha(v)beta3, whereas cell death was observed in foci in which immunoreactivities for these factors were weak or absent. No association was found with thrombospondin immunoreactivity. The balance between angiogenesis and vascular regression in rheumatoid synovitis may be determined by the focal expression of angiogenic and endothelial survival factors. Increased endothelial cell turnover may contribute to microvascular dysfunction and thereby facilitate persistent synovitis.
Indexed as
Identifiers
9502411PMC1858385W144917492What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.