ArticleApplied and environmental microbiology1998
The citrate transport system of Lactococcus lactis subsp. lactis biovar diacetylactis is induced by acid stress.
Article in Applied and environmental microbiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Alkaline pH-Driven Metabolic Plasticity of Lactococcus lactis FM03.Environmental microbiology · 2025Article
- Citrate metabolism in lactic acid bacteria: is there a beneficial effect forFrontiers in microbiology · 2023Review
- Identification of Potential Citrate Metabolism Pathways inMicroorganisms · 2021Article
- Precise Populations' Description in Dairy Ecosystems Using Digital Droplet PCR: The Case ofFrontiers in microbiology · 2020Article
- Article
- Comparative Genome Analysis ofFrontiers in microbiology · 2019Article
- Large plasmidome of dairy Lactococcus lactis subsp. lactis biovar diacetylactis FM03P encodes technological functions and appears highly unstable.BMC genomics · 2018Article
- Citrate, low pH and amino acid limitation induce citrate utilization in Lactococcus lactis biovar diacetylactis.Microbial biotechnology · 2018Article
- Mapping the Physiological Response ofFrontiers in microbiology · 2018Article
- Draft Genome Sequence of Lactococcus lactis subsp. lactis bv. diacetylactis CRL264, a Citrate-Fermenting Strain.Genome announcements · 2016Article
- Functional implications of the microbial community structure of undefined mesophilic starter cultures.Microbial cell factories · 2014Review
- Uptake of α-ketoglutarate by citrate transporter CitP drives transamination in Lactococcus lactis.Applied and environmental microbiology · 2013Article
- Rerouting citrate metabolism in Lactococcus lactis to citrate-driven transamination.Applied and environmental microbiology · 2012Article
- Substrate specificity of the citrate transporter CitP of Lactococcus lactis.Journal of bacteriology · 2012Article
- Differential response of Streptococcus mutans towards friend and foe in mixed-species cultures.Microbiology (Reading, England) · 2011Article
- Mechanism of citrate metabolism by an oxaloacetate decarboxylase-deficient mutant of Lactococcus lactis IL1403.Journal of bacteriology · 2011Article
- Citrate uptake in exchange with intermediates in the citrate metabolic pathway in Lactococcus lactis IL1403.Journal of bacteriology · 2011Article
- Dynamic analysis of the Lactococcus lactis transcriptome in cheeses made from milk concentrated by ultrafiltration reveals multiple strategies of adaptation to stresses.Applied and environmental microbiology · 2011Article
- Adaptative potential of the Lactococcus lactis IL594 strain encoded in its 7 plasmids.PloS one · 2011Article
- Acid tolerance mechanisms utilized by Streptococcus mutans.Future microbiology · 2010Review
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4 authors.
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Abstract
Citrate transport in Lactococcus lactis subsp. lactis biovar diacetylactis is catalyzed by citrate permease P (CitP), which is encoded by the plasmidic citP gene. We have shown previously that citP is included in the citQRP operon, which is mainly transcribed from the P1 promoter in L. lactis subsp. lactis biovar diacetylactis. furthermore, transcription of citQRP and citrate transport are not induced by the presence of citrate in the growth medium. In this work, we analyzed the influence of the extracellular pH on the expression of citP. The citrate transport system is induced by natural acidification of the medium during cell growth and by a shift to media buffered at acidic pHs. This inducible response to acid stress takes place at the transcriptional level and seems to be due to increased utilization of the P1 promoter. Increased transcription correlates with increased synthesis of CitP and results in higher citrate transport activity catalyzed by the cells. Finally, this acid stress response seems to provide L. lactis subsp. lactis biovar diacetylactis with a selective advantage resulting from cometabolism of glucose and citrate at low pHs.
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