ArticleProceedings of the National Academy of Sciences of the United States of America1998
In vivo phosphorylation of the epithelial sodium channel.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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Who cites it
42 citing papers in PubMed, 170 citations in OpenAlex.
- Aldosterone: Renal Action and Physiological Effects.Comprehensive Physiology · 2023Article
- The Post-Translational Modification Networking in WNK-Centric Hypertension Regulation and Electrolyte Homeostasis.Biomedicines · 2022Review
- PKC regulation of ion channels: The involvement of PIPThe Journal of biological chemistry · 2022Review
- Does the early aldosterone-induced SGK1 play a role in early Kaliuresis?Physiological reports · 2022Article
- Article
- Genomic and rapid effects of aldosterone: what we know and do not know thus far.Heart failure reviews · 2017Review
- Formaldehyde impairs transepithelial sodium transport.Scientific reports · 2016Article
- Liddle-Mutation of the β-Subunit, but not the γ-Subunit, Attenuates Protein Kinase C-Mediated Inhibition of Human Epithelial Sodium Channels (hENaC).The Journal of membrane biology · 2016Article
- Cross-talk between insulin and IGF-1 receptors in the cortical collecting duct principal cells: implication for ENaC-mediated Na+ reabsorption.American journal of physiology. Renal physiology · 2015Article
- Receptor for advanced glycation end-products regulates lung fluid balance via protein kinase C-gp91(phox) signaling to epithelial sodium channels.American journal of respiratory cell and molecular biology · 2015Article
- Rapid elevation of sodium transport through insulin is mediated by AKT in alveolar cells.Physiological reports · 2014Article
- Rapid stimulation of human renal ENaC by cAMP in Xenopus laevis oocytes.Journal of physiology and biochemistry · 2013Article
- Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation.The Journal of biological chemistry · 2013Article
- Reduced ENaC activity and blood pressure in mice with genetic knockout of the insulin receptor in the renal collecting duct.American journal of physiology. Renal physiology · 2013Article
- Epithelial Na(+) channel regulation by cytoplasmic and extracellular factors.Experimental cell research · 2012Review
- Regulation of alveolar epithelial Na+ channels by ERK1/2 in chlorine-breathing mice.American journal of respiratory cell and molecular biology · 2012Article
- Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC).American journal of physiology. Renal physiology · 2011Article
- NKCC2 is activated in Milan hypertensive rats contributing to the maintenance of salt-sensitive hypertension.Pflugers Archiv : European journal of physiology · 2011Article
- 8-pCPT-cGMP stimulates alphabetagamma-ENaC activity in oocytes as an external ligand requiring specific nucleotide moieties.American journal of physiology. Renal physiology · 2010Article
- Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The activity of the epithelial sodium channel (ENaC) in the distal nephron is regulated by an antidiuretic hormone, aldosterone, and insulin, but the molecular mechanisms that mediate these hormonal effects are mostly unknown. We have investigated whether aldosterone, insulin, or activation of protein kinases has an effect on the phosphorylation of the channel. Experiments were performed in an epithelial cell line generated by stable cotransfection of the three subunits (alpha, beta, and gamma) of ENaC. We found that beta and gamma, but not the alpha subunit, are phosphorylated in the basal state. Aldosterone, insulin, and protein kinases A and C increased phosphorylation of the beta and gamma subunits in their carboxyl termini, but none of these agents induced de novo phosphorylation of alpha subunits. Serines and threonines but not tyrosines were found to be phosphorylated. The results suggest that aldosterone, insulin, and protein kinases A and C modulate the activity of ENaC by phosphorylation of the carboxyl termini of the beta and gamma subunits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.