ArticleProceedings of the National Academy of Sciences of the United States of America1998
The neural restrictive silencer element can act as both a repressor and enhancer of L1 cell adhesion molecule gene expression during postnatal development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 75 citations in OpenAlex.
- Phosphorylation by CaMKIV regulates the transcriptional repressor activity and half-life of REST/NRSF.Science advances · 2026Article
- Characterization of a cis-regulatory element upstream of matrix metalloproteinase-9.Scientific reports · 2025Article
- A dual enhancer-attenuator element ensures transient Cdx2 expression during mouse posterior body formation.Developmental cell · 2025Article
- Chromatin structure and 3D architecture define the differential functions of PU.1 regulatory elements in blood cell lineages.Epigenetics & chromatin · 2024Article
- Building integrative functional maps of gene regulation.Human molecular genetics · 2022Article
- Long-Distance Repression by Human Silencers: Chromatin Interactions and Phase Separation in Silencers.Cells · 2022Review
- REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion.eLife · 2021Article
- The microRNA/TET3/REST axis is required for olfactory globose basal cell proliferation and male behavior.EMBO reports · 2020Article
- Transcriptional Silencers in Drosophila Serve a Dual Role as Transcriptional Enhancers in Alternate Cellular Contexts.Molecular cell · 2020Article
- lncRNA PSORS1C3 is regulated by glucocorticoids and fine-tunes OCT4 expression in non-pluripotent cells.Scientific reports · 2019Article
- Desmosterol in brain is elevated because DHCR24 needs REST for Robust Expression but REST is poorly expressed.Developmental neuroscience · 2014Article
- REST interacts with Cbx proteins and regulates polycomb repressive complex 1 occupancy at RE1 elements.Molecular and cellular biology · 2011Article
- Regulated expression of the Ras effector Rin1 in forebrain neurons.Molecular and cellular neurosciences · 2010Article
- Nuclear factor I-A represses expression of the cell adhesion molecule L1.BMC molecular biology · 2009Article
- A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- A newly modified SCG10 promoter and Cre/loxP-mediated gene amplification system achieve highly specific neuronal expression in animal brains.Gene therapy · 2006Article
- Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The C264Y missense mutation in the extracellular domain of L1 impairs protein trafficking in vitro and in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Repressor element-1 silencing transcription/neuron-restrictive silencer factor is required for neural sodium channel expression during development of Xenopus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Expression of brain-derived neurotrophic factor in cortical neurons is regulated by striatal target area.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The cell adhesion molecule L1 mediates axonal guidance during neural development and mutations in its gene result in severe neurological defects. In previous studies, we identified the promoter for the L1 gene and showed that a neural restrictive silencer element (NRSE) was critical for preventing ectopic expression of L1 during early embryonic development. In the present study, we have investigated the role of the NRSE in the regulation of L1 expression during postnatal development. In gel mobility shift experiments, the NRSE formed DNA-protein complexes with nuclear extracts prepared from the brains of postnatal mice. To examine the influence of the NRSE on postnatal patterns of L1 expression in vivo, we compared the expression of two lacZ transgene constructs, one containing the native L1 gene regulatory sequences (L1lacZ) and another (L1lacZDeltaN) lacking the NRSE. Newborn mice carrying the L1lacZDeltaN showed enhanced beta-galactosidase expression relative to L1lacZ in the brain and ectopic expression in nonneural tissues. In contrast to L1lacZ mice, however, L1lacZDeltaN mice showed an unexpected loss, during postnatal development and in the adult, of beta-galactosidase expression in several neural structures, including the neural retina, cerebellum, cortex, striatum, and hippocampus. These data support the conclusion that the NRSE not only plays a role in the silencing of L1 expression in nonneural tissues during early development but also can function as a silencer and an enhancer of L1 expression in the nervous system of postnatal and adult animals.
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