ArticleProceedings of the National Academy of Sciences of the United States of America1998
Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 133 citations in OpenAlex.
- Double Positive CD4Frontiers in immunology · 2019Trial
- CD4+CD8+ T cells represent a significant portion of the anti-HIV T cell response to acute HIV infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Trial
- Productive human immunodeficiency virus type 1 infection in peripheral blood predominantly takes place in CD4/CD8 double-negative T lymphocytes.Journal of virology · 2007Trial
- Functionally heterogeneous intratumoral CD4Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Association of leukocyte count with death in people with HIV: A longitudinal study over 24 years.PloS one · 2026Article
- Spatial iTME analysis of KRAS mutant NSCLC and immunotherapy outcome.NPJ precision oncology · 2024Article
- Increased CD4Viruses · 2022Article
- CD4Journal of virology · 2022Article
- Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4Nature immunology · 2021Article
- Clonal expansion of CD4Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021Article
- CD32 is enriched on CD4dimCD8bright T cells.PloS one · 2020Observational
- CD4Frontiers in immunology · 2020Article
- How HIV Nef Proteins Hijack Membrane Traffic To Promote Infection.Journal of virology · 2019Review
- A rare population of tumor antigen-specific CD4Journal for immunotherapy of cancer · 2019Article
- Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor.PLoS pathogens · 2017Article
- Different cytokine profiles of skin-derived T cell cultures from patients with atopic dermatitis and psoriasis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Migration of CD8+ T Cells into the Central Nervous System Gives Rise to Highly Potent Anti-HIV CD4dimCD8bright T Cells in a Wnt Signaling-Dependent Manner.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- The transcription factors Thpok and LRF are necessary and partly redundant for T helper cell differentiation.Immunity · 2012Article
- Down-modulation of CD8αβ is a fundamental activity of primate lentiviral Nef proteins.Journal of virology · 2012Article
- Vaginal langerhans cells nonproductively transporting HIV-1 mediate infection of T cells.Journal of virology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T cell activation through the T cell receptor is necessary to achieve a specific and effective immune response. We report here that stimulation of CD8+ T cells through the T cell receptor complex leads to de novo expression of the CD4 antigen on the cell surface that results in susceptibility of CD8+ T cells to HIV infection. In addition, activation of peripheral blood mononuclear cells from HIV-infected individuals results in the appearance of double-positive CD4+/CD8+ T cells, which become infected by endogenous HIV. HIV DNA sequences could be detected in uncultured and sorted mature CD3+CD8+ T cells from HIV+ individuals. These results suggest a new mechanism by which HIV could attack the immune system and may help to explain the CD8+ T cell defects in AIDS patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.