ArticleProceedings of the National Academy of Sciences of the United States of America1998
Homeobox genes in the ribbonworm Lineus sanguineus: evolutionary implications.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 72 citations in OpenAlex.
- An Overview ofJournal of developmental biology · 2016Review
- Hox genes pattern the anterior-posterior axis of the juvenile but not the larva in a maximally indirect developing invertebrate, Micrura alaskensis (Nemertea).BMC biology · 2015Article
- Functional synthetic Antennapedia genes and the dual roles of YPWM motif and linker size in transcriptional activation and repression.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Function and specificity of synthetic Hox transcription factors in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Genomic organization and expression demonstrate spatial and temporal Hox gene colinearity in the lophotrochozoan Capitella sp. I.PloS one · 2008Article
- Pre-bilaterian origins of the Hox cluster and the Hox code: evidence from the sea anemone, Nematostella vectensis.PloS one · 2007Article
- Hox gene expression in larval development of the polychaetes Nereis virens and Platynereis dumerilii (Annelida, Lophotrochozoa).Development genes and evolution · 2007Article
- Hox gene survey in the chaetognath Spadella cephaloptera: evolutionary implications.Development genes and evolution · 2003Article
- The fates of zebrafish Hox gene duplicates.Journal of structural and functional genomics · 2003Review
- HOX genes in the sepiolid squid Euprymna scolopes: implications for the evolution of complex body plans.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Reverse homeosis in homeotically reconstructed ribbonworms.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- The anterior determinant bicoid of Drosophila is a derived Hox class 3 gene.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Regeneration as an evolutionary variable.Journal of anatomyReview
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
From our current understanding of the genetic basis of development and pattern formation in Drosophila and vertebrates it is commonly thought that clusters of Hox genes sculpt the morphology of animals in specific body regions. Based on Hox gene conservation throughout the animal kingdom it is proposed that these genes and their role in pattern formation evolved early during the evolution of metazoans. Knowledge of the history of Hox genes will lead to a better understanding of the role of Hox genes in the evolution of animal body plans. To infer Hox gene evolution, reliable data on lower chordates and invertebrates are crucial. Among the lower triploblasts, the body plan of the ribbonworm Lineus (nemertini) appears to be close to the common ancestral condition of protostomes and deuterostomes. In this paper we present the isolation and identification of Hox genes in Lineus sanguineus. We find that the Lineus genome contains a single cluster of at least six Hox genes: two anterior-class genes, three middle-class genes, and one posterior-class gene. Each of the genes can be definitely assigned to an ortholog group on the basis of its homeobox and its flanking sequences. The most closely related homeodomain sequences are invariably found among the mouse or Amphioxus orthologs, rather than Drosophila and other invertebrates. This suggests that the ribbonworms have diverged relatively little from the last common ancestors of protostomes and deuterostomes, the urbilateria.
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