ArticleProceedings of the National Academy of Sciences of the United States of America1998
Computational learning reveals coiled coil-like motifs in histidine kinase linker domains.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 78 citations in OpenAlex.
- Untangling the Complexity of Two-Component Signal Transduction in Bacteria.Microorganisms · 2025Review
- Decoding plant thermosensors: mechanism of temperature perception and stress adaption.Frontiers in plant science · 2025Review
- Allostery and protein plasticity: the keystones for bacterial signaling and regulation.Biophysical reviews · 2021Review
- Identification of Uncharacterized Components of Prokaryotic Immune Systems and Their Diverse Eukaryotic Reformulations.Journal of bacteriology · 2020Article
- Mutational analysis of dimeric linkers in peri- and cytoplasmic domains of histidine kinase DctB reveals their functional roles in signal transduction.Open biology · 2014Article
- An analysis of the solution structure and signaling mechanism of LovK, a sensor histidine kinase integrating light and redox signals.Biochemistry · 2010Article
- The S helix mediates signal transmission as a HAMP domain coiled-coil extension in the NarX nitrate sensor from Escherichia coli K-12.Journal of bacteriology · 2010Article
- Genetic and biochemical analysis of the SLN1 pathway in Saccharomyces cerevisiae.Methods in enzymology · 2010Article
- Conserved residues in the HAMP domain define a new family of proposed bipartite energy taxis receptors.Journal of bacteriology · 2009Article
- Integration of rotation and piston motions in coiled-coil signal transduction.Journal of bacteriology · 2007Article
- The signaling helix: a common functional theme in diverse signaling proteins.Biology direct · 2006Article
- Structure of the entire cytoplasmic portion of a sensor histidine-kinase protein.The EMBO journal · 2005Article
- A conserved trimerization motif controls the topology of short coiled coils.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Analysis of chimeric chemoreceptors in Bacillus subtilis reveals a role for CheD in the function of the McpC HAMP domain.Journal of bacteriology · 2004Article
- Diversity in chemotaxis mechanisms among the bacteria and archaea.Microbiology and molecular biology reviews : MMBR · 2004Review
- Probing conservation of HAMP linker structure and signal transduction mechanism through analysis of hybrid sensor kinases.Journal of bacteriology · 2003Article
- Mutational analysis of a conserved signal-transducing element: the HAMP linker of the Escherichia coli nitrate sensor NarX.Journal of bacteriology · 2003Article
- Protein sequences and cellular factors required for polar localization of a histidine kinase in Caulobacter crescentus.Journal of bacteriology · 2002Article
- Domain interactions on the ntr signal transduction pathway: two-hybrid analysis of mutant and truncated derivatives of histidine kinase NtrB.Journal of bacteriology · 2002Article
- A cytoplasmic coiled-coil domain is required for histidine kinase activity of the yeast osmosensor, SLN1.Molecular microbiology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recent rapid growth of protein sequence databases is outpacing the capacity of researchers to biochemically and structurally characterize new proteins. Accordingly, new methods for recognition of motifs and homologies in protein primary sequences may be useful in determining how these proteins might function. We have applied such a method, an iterative learning algorithm, to analyze possible coiled coil domains in histidine kinase receptors. The potential coiled coils have not yet been structurally characterized in any histidine kinase, and they appear outside previously noted kinase homology regions. The learning algorithm uses a combination of established sequence patterns in known coiled coil proteins and histidine kinase sequence data to learn to recognize efficiently this coiled coil-like motif in the histidine kinases. The common appearance of the structural motif in a functionally important part of the receptors suggests hypotheses for kinase regulation and signal transduction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.