ArticleThe EMBO journal1998
Selectivity, sharing and competitive interactions in the regulation of Hoxb genes.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
58 citing papers in PubMed, 168 citations in OpenAlex.
- HOXA5-driven transcriptional program in lung development.Developmental biology · 2025Article
- Biology of Hox Genes: Questions and Technological Challenges.Methods in molecular biology (Clifton, N.J.) · 2025Review
- DNA regulatory element cooperation and competition in transcription.BMB reports · 2024Review
- Review
- Shared retinoic acid responsive enhancers coordinately regulate nascent transcription of Hoxb coding and non-coding RNAs in the developing mouse neural tube.Development (Cambridge, England) · 2023Article
- Hox genes in development and beyond.Development (Cambridge, England) · 2023Article
- The transcriptomic landscape of caudal cell mass in different developmental stages of the chick embryo.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Functional genomic assays to annotate enhancer-promoter interactions genome wide.Human molecular genetics · 2022Review
- Transcriptional Regulation and Implications for ControllingJournal of developmental biology · 2022Review
- Genomic environments scale the activities of diverse core promoters.Genome research · 2022Article
- Annotation of Hox cluster and Hox cofactor genes in the Asian citrus psyllid,GigaByte (Hong Kong, China) · 2022Article
- Segmentation and patterning of the vertebrate hindbrain.Development (Cambridge, England) · 2021Review
- Article
- The regulatory landscapes of developmental genes.Development (Cambridge, England) · 2020Review
- SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expression.Genes & development · 2017Article
- Clustered brachiopod Hox genes are not expressed collinearly and are associated with lophotrochozoan novelties.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Different enhancer classes in Drosophila bind distinct architectural proteins and mediate unique chromatin interactions and 3D architecture.Nucleic acids research · 2017Article
- Regulatory Enhancer-Core-Promoter Communication via Transcription Factors and Cofactors.Trends in genetics : TIG · 2016Review
- The role of enhancers in cancer.Nature reviews. Cancer · 2016Review
- Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan.eLife · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clustered organisation of Hox complexes is highly conserved in vertebrates and the reasons for this are believed to be linked with the regulatory mechanisms governing their expression. In analysis of the Hoxb4-Hoxb6 region of the HoxB complex we identified enhancers which lie in the intergenic region between Hoxb4 and Hoxb5, and which are capable of mediating the correct boundaries of neural and mesodermal expression for Hoxb5. We examined their regulatory properties in the context of the local genomic region spanning the two genes by transgenic analysis, in which each promoter was independently marked with a different reporter, to monitor simultaneously the relative transcriptional read-outs from each gene. Our analysis revealed that within this intergenic region: (i) a limb and a neural enhancer selectively activate Hoxb4 as opposed to Hoxb5; (ii) a separate neural enhancer is able to activate both genes, but expression is dependent upon competition between the two promoters for the enhancer and is influenced by the local genomic context; (iii) mesodermal enhancer activities can be shared between the genes. We found similar types of regulatory interactions between Hoxb5 and Hoxb6. Together these results provide evidence for three separate general mechanisms: selectivity, competition and sharing, that control the balance of cis-regulatory interactions necessary for generating the proper spatial and temporal patterns of Hox gene expression. We suggest that these mechanisms are part of a regulatory basis for maintenance of Hox organisation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.