ArticleThe EMBO journal1998
Disruption of the HSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 118 citations in OpenAlex.
- Adaptation to heat stress by diversification of the vertebrate heat shock transcription factor family.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Genome-wide characterization of HSP70 and HSP90 subfamilies in Yak (Bos grunniens): expression patterns under cold and chemical hypoxia conditions.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- A guide to heat shock factors as multifunctional transcriptional regulators.The FEBS journal · 2025Review
- Impact of Thermal Manipulation of Broiler Eggs on Growth Performance, Splenic Inflammatory Cytokine Levels, and Heat Shock Protein Responses to Post-Hatch Lipopolysaccharide (LPS) Challenge.Animals : an open access journal from MDPI · 2025Article
- The Function of Heat Shock Transcription Factors in Sex Differentiation inAnimals : an open access journal from MDPI · 2025Article
- HSF1 is required for cellular adaptation to daily temperature fluctuations.Scientific reports · 2024Article
- Heat Shock Response and Heat Shock Proteins: Current Understanding and Future Opportunities in Human Diseases.International journal of molecular sciences · 2024Review
- Role of Heat Shock Factors in Stress-Induced Transcription: An Update.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Dietary supplementation of dried plum: a novel strategy to mitigate heat stress in broiler chickens.Journal of animal science and biotechnology · 2021Article
- Enriched environment housing improved the laying hen's resistance to transport stress via modulating the heat shock protective response and inflammation.Poultry science · 2021Article
- Impacts of Embryonic Thermal Programming on the Expression of Genes Involved inFrontiers in physiology · 2021Article
- HSF3 and Hsp70 Expression during Post-Hatch Cold Stress in Broiler Chickens Subjected to Embryonic Thermal Manipulation.Veterinary sciences · 2020Article
- Tailoring of Proteostasis Networks with Heat Shock Factors.Cold Spring Harbor perspectives in biology · 2019Review
- Sexual Dimorphism and Aging Differentially Regulate Adaptive Homeostasis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Role of Heat Shock Factors in Stress-Induced Transcription.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Co-enzyme Q10 and acetyl salicylic acid enhance Hsp70 expression in primary chicken myocardial cells to protect the cells during heat stress.Molecular and cellular biochemistry · 2017Article
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- Zebrafish HSF4: a novel protein that shares features of both HSF1 and HSF4 of mammals.Cell stress & chaperones · 2012Article
- Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation.Molecular biology of the cell · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vertebrate genome encodes a family of heat shock factors (HSFs 1-4) of which the DNA-binding and transcriptional activities of HSF1 and HSF3 are activated upon heat shock. HSF1 has the properties of a classical HSF and exhibits rapid activation of DNA-binding and transcriptional activity upon exposure to conditions of heat shock and other stresses, whereas HSF3 typically is activated at higher temperatures and with distinct delayed kinetics. To address the role of HSF3 in the heat shock response, null cells lacking the HSF3 gene were constructed by disruption of the resident gene by somatic recombination in an avian lymphoid cell line. Null cells lacking HSF3, yet expressing normal levels of HSF1, exhibited a severe reduction in the heat shock response, as measured by inducible expression of heat shock genes, and did not exhibit thermotolerance. At intermediate heat shock temperatures, where HSF1 oligomerizes to an active trimer in wild-type cells, HSF1 remained as an inert monomer in the HSF3 null cell line. HSF3 null cells were restored to a nearly normal heat shock-responsive state by reintroduction of an exogenous HSF3 gene. These results reveal that HSF3 has a dominant role in the regulation of the heat shock response and directly influences HSF1 activity.
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