ArticleJournal of virology1998
Anchorage-independent transcription of the cyclin A gene induced by the E7 oncoprotein of human papillomavirus type 16.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- How human papillomavirus (HPV) targets DNA repair pathways for viral replication: from guardian to accomplice.Microbiology and molecular biology reviews : MMBR · 2025Review
- Uridine Cytidine Kinase Like-1 Enhances Tumor Cell Proliferation and Mediates Protection from Natural Killer-Mediated Killing.International journal of immunology and immunotherapy · 2016Article
- The papillomavirus E7 proteins.Virology · 2013Review
- Human papillomavirus type 16 E7 oncoprotein associates with E2F6.Journal of virology · 2008Article
- Effect of transforming viruses on molecular mechanisms associated with cancer.Journal of cellular physiology · 2008Review
- Human papillomavirus E7 oncoprotein dysregulates steroid receptor coactivator 1 localization and function.Journal of virology · 2006Article
- The E7 oncoprotein is translated from spliced E6*I transcripts in high-risk human papillomavirus type 16- or type 18-positive cervical cancer cell lines via translation reinitiation.Journal of virology · 2006Article
- Short-term induction and long-term suppression of HPV16 oncogene silencing by RNA interference in cervical cancer cells.Oncogene · 2006Article
- Human papillomavirus type 16 E7 oncoprotein can induce abnormal centrosome duplication through a mechanism independent of inactivation of retinoblastoma protein family members.Journal of virology · 2003Article
- Molecular interactions of 'high risk' human papillomaviruses E6 and E7 oncoproteins: implications for tumour progression.Journal of biosciences · 2003Review
- E7 abolishes raf-induced arrest via mislocalization of p21(Cip1).Molecular and cellular biology · 2002Article
- Human papillomaviruses and centrosome duplication errors: modeling the origins of genomic instability.Oncogene · 2002Review
- Distinct effects of mitogens and the actin cytoskeleton on CREB and pocket protein phosphorylation control the extent and timing of cyclin A promoter activity.Molecular and cellular biology · 2001Article
- Destabilization of the retinoblastoma tumor suppressor by human papillomavirus type 16 E7 is not sufficient to overcome cell cycle arrest in human keratinocytes.Journal of virology · 2001Article
- Biology of human papillomaviruses.International journal of experimental pathology · 2001Review
- Strategies in subversion: de-regulation of the mammalian cell cycle by viral gene products.International journal of experimental pathology · 2001Review
- Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To develop an experimental model for E7-mediated anchorage-independent growth, we studied the ability of E7-expressing NIH 3T3 subclones to enter S phase when they were cultured in suspension. We found that expression of E7 prevents the inhibition of cyclin E-associated kinase and also triggers activation of cyclin A gene expression in suspension cells. A point mutation in the amino terminus of E7 prevented E7-driven rescue of cyclin E-associated kinase activity in suspension cells; however, cells with this mutation retained some ability to activate cyclin A gene expression and promote S-phase entry. Activation of cyclin A gene expression by E7 was correlated with an increased binding of free E2F to a regulatory element in the cyclin A promoter which mediates both repression of cyclin A upon loss of adhesion and its reactivation by E7. Surprisingly, expression of E7 led to a nuclear accumulation of one species of free E2F, namely, an E2F-4-DP-1 heterodimer, that is exclusively cytoplasmic in the absence of E7. Taken together, the data reported here indicate that several different E7-dependent changes of cellular-growth-regulating pathways can cooperate to allow adhesion-independent entry into S phase.
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