ArticleJournal of virology1998
Functional characterization of naturally occurring variants of human hepatitis B virus containing the core internal deletion mutation.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 60 citations in OpenAlex.
- Low pathogenic avian influenza virus isolates with different levels of defective genome segments vary in pathogenicity and transmission efficiency.Veterinary research · 2020Article
- Persistence of Hepatitis B Virus DNA and the Tempos between Virion Secretion and Genome Maturation in a Mouse Model.Journal of virology · 2019Article
- Article
- HBV polymerase overexpression due to large core gene deletion enhances hepatoma cell growth by binding inhibition of microRNA-100.Oncotarget · 2016Article
- Increased expression of Gp96 by HBx-induced NF-κB activation feedback enhances hepatitis B virus production.PloS one · 2013Article
- Conformational changes in the hepatitis B virus core protein are consistent with a role for allostery in virus assembly.Journal of virology · 2010Article
- Virologic characteristics of hepatitis B virus in patients infected via maternal-fetal transmission.World journal of gastroenterology · 2008Article
- Comparison of complete sequences of hepatitis B virus genotype C between inactive carriers and hepatocellular carcinoma patients before and after seroconversion.Journal of gastroenterology · 2007Article
- A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Hepatitis B virus capsid assembly is enhanced by naturally occurring mutation F97L.Journal of virology · 2004Article
- The 113th and 117th charged amino acids in the 5th alpha-helix of the HBV core protein are necessary for pgRNA encapsidation.Virus genes · 2003Article
- Stability and morphology comparisons of self-assembled virus-like particles from wild-type and mutant human hepatitis B virus capsid proteins.Journal of virology · 2003Article
- Replication advantage and host factor-independent phenotypes attributable to a common naturally occurring capsid mutation (I97L) in human hepatitis B virus.Journal of virology · 2002Article
- Replication of naturally occurring woodchuck hepatitis virus deletion mutants in primary hepatocyte cultures and after transmission to naive woodchucks.Journal of virology · 2001Article
- Low-level secretion of human hepatitis B virus virions caused by two independent, naturally occurring mutations (P5T and L60V) in the capsid protein.Journal of virology · 2000Article
- Hepatitis B virus core gene mutations which block nucleocapsid envelopment.Journal of virology · 2000Article
- Subtype-independent immature secretion and subtype-dependent replication deficiency of a highly frequent, naturally occurring mutation of human hepatitis B virus core antigen.Journal of virology · 1999Article
- The mechanism of an immature secretion phenotype of a highly frequent naturally occurring missense mutation at codon 97 of human hepatitis B virus core antigen.Journal of virology · 1999Article
- Extensive mutagenesis of the hepatitis B virus core gene and mapping of mutations that allow capsid formation.Journal of virology · 1999Article
- A defective interference-like phenomenon of human hepatitis B virus in chronic carriers.Journal of virology · 1998Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Naturally occurring variants of human hepatitis B virus (HBV) containing the core internal deletion (CID) mutation have been found frequently in HBV carriers worldwide. Despite numerous sequence analysis reports of CID variants in patients, in the past decade, CID variants have not been characterized functionally, and thus their biological significance to HBV infection remains unclear. We report here two different CID variants identified from two patients that are replication defective, most likely due to the absence of detectable core protein. In addition, we were unable to detect the presence of the precore protein and e antigen from CID variants. However, the production of polymerase appeared to be normal. The replication defect of the CID variants can be rescued in trans by complementation with wild-type core protein. The rescued CID variant particles, which utilize the wild-type core protein, presumably are enveloped properly since they can be secreted into the medium and band at a position similar to that of mature wild-type Dane particles, as determined by gradient centrifugation analysis. Our results also provide an explanation for the association of CID variants with helper or wild-type HBV in nature. The significance of CID variants in HBV infection and pathogenesis is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.