ArticleJournal of virology1998
Chimeric measles viruses with a foreign envelope.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 117 citations in OpenAlex.
- Oligomerization and Cell Egress Controlled by Two Microdomains of Canine Distemper Virus Matrix Protein.mSphere · 2021Article
- Article
- The glutamic residue at position 402 in the C-terminus of Newcastle disease virus nucleoprotein is critical for the virus.Scientific reports · 2017Article
- Dimerization Efficiency of Canine Distemper Virus Matrix Protein Regulates Membrane-Budding Activity.Journal of virology · 2017Article
- Measles virus.Human vaccines & immunotherapeutics · 2015Review
- Paramyxovirus glycoprotein incorporation, assembly and budding: a three way dance for infectious particle production.Viruses · 2014Review
- Applications and challenges of multivalent recombinant vaccines.Human vaccines & immunotherapeutics · 2013Review
- Sequence and immunogenicity of a clinically approved novel measles virus vaccine vector.Human vaccines & immunotherapeutics · 2013Article
- F-actin modulates measles virus cell-cell fusion and assembly by altering the interaction between the matrix protein and the cytoplasmic tail of hemagglutinin.Journal of virology · 2013Article
- Development of measles virus-based shielded oncolytic vectors: suitability of other paramyxovirus glycoproteins.Cancer gene therapy · 2013Article
- Broadly neutralizing immune responses against hepatitis C virus induced by vectored measles viruses and a recombinant envelope protein booster.Journal of virology · 2012Article
- Electron cryotomography of measles virus reveals how matrix protein coats the ribonucleocapsid within intact virions.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Matrix protein-specific IgA antibody inhibits measles virus replication by intracellular neutralization.Journal of virology · 2011Article
- Emerging zoonotic viruses: new lessons on receptor and entry mechanisms.Current opinion in virology · 2011Review
- DC-SIGN mediated sphingomyelinase-activation and ceramide generation is essential for enhancement of viral uptake in dendritic cells.PLoS pathogens · 2011Article
- Refined methods for propagating vesicular stomatitis virus vectors that are defective for G protein expression.Journal of virological methods · 2010Article
- Contribution of matrix, fusion, hemagglutinin, and large protein genes of the CAM-70 measles virus vaccine strain to efficient growth in chicken embryonic fibroblasts.Journal of virology · 2009Article
- The matrix protein of measles virus regulates viral RNA synthesis and assembly by interacting with the nucleocapsid protein.Journal of virology · 2009Article
- Glycoprotein interactions in paramyxovirus fusion.Future virology · 2009Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Measles virus (MV) and vesicular stomatitis virus (VSV) are both members of the Mononegavirales but are only distantly related. We generated two genetically stable chimeric viruses. In MGV, the reading frames of the MV envelope glycoproteins H and F were substituted by a single reading frame encoding the VSV G glycoprotein; MG/FV is similar but encodes a G/F hybrid in which the VSV G cytoplasmic tail was replaced by that of MV F. In contrast to MG/FV, MGV virions do not contain the MV matrix (M) protein. This demonstrates that virus assembly is possible in the absence of M; conversely, the cytoplasmic domain of F allows incorporation of M and enhances assembly. The formation of chimeric viruses was substantially delayed and the titers obtained were reduced about 50-fold in comparison to standard MV. In the novel chimeras, transcription and replication are mediated by the MV ribonucleoproteins but the envelope glycoproteins dictate the host range. Mice immunized with the chimeric viruses were protected against lethal doses of wild-type VSV. These findings suggest that it is feasible to construct MV variants bearing a variety of different envelopes for use as vaccines or for gene therapeutic purposes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.