ArticleJournal of virology1998
Human endogenous retrovirus K homologous sequences and their coding capacity in Old World primates.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- The identification of retro-DNAs in primate genomes as DNA transposons mobilizing via retrotransposition.F1000Research · 2023Article
- Prolonged activity of HERV-K(HML2) in Old World Monkeys accounts for recent integrations and novel recombinant variants.Frontiers in microbiology · 2022Article
- How Retroviruses and Retrotransposons in Our Genome May Contribute to Autoimmunity in Rheumatological Conditions.Frontiers in immunology · 2020Review
- Genome-wide amplification of proviral sequences reveals new polymorphic HERV-K(HML-2) proviruses in humans and chimpanzees that are absent from genome assemblies.Retrovirology · 2015Article
- Np9, a cellular protein of retroviral ancestry restricted to human, chimpanzee and gorilla, binds and regulates ubiquitin ligase MDM2.Cell cycle (Georgetown, Tex.) · 2015Article
- Article
- Distinct retroelement classes define evolutionary breakpoints demarcating sites of evolutionary novelty.BMC genomics · 2009Article
- Expression pattern analysis of transcribed HERV sequences is complicated by ex vivo recombination.Retrovirology · 2007Article
- Allelic variation of HERV-K(HML-2) endogenous retroviral elements in human populations.Journal of molecular evolution · 2004Article
- Human endogenous retrovirus family HERV-K(HML-5): status, evolution, and reconstruction of an ancient betaretrovirus in the human genome.Journal of virology · 2004Article
- Presence of dUTPase in the various human endogenous retrovirus K (HERV-K) families.Journal of molecular evolution · 2003Article
- The evolution, distribution and diversity of endogenous retroviruses.Virus genes · 2003Review
- HERV-K(OLD): ancestor sequences of the human endogenous retrovirus family HERV-K(HML-2).Journal of virology · 2001Article
- Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.Journal of virology · 1999Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The coding capacity for retroviral Gag and Env proteins has been maintained in human endogenous retroviruses of the HERV-K family. HERV-K homologous sequences have been found in all Old World primates. Here, we examined Old World primate species for the presence of full-length HERV-K gag and env genes and the presence of gag and env open reading frames as determined by the protein truncation test. Full-length HERV-K env genes were found in DNAs of all Old World primate species, whereas open reading frames for Env protein were found solely in human, chimpanzee, and gorilla DNAs. The mutational event leading to two HERV-K types was found to have occurred after the separation of hominids from lower Old World primates and before the expansion of hominids. Full-length HERV-K gag genes in hominids displayed a 96-bp deletion compared to those in lower Old World primates. The ancient gag variant has not been maintained during hominid evolution. Open reading frames for HERV-K Gag have been found in all Old World primates except chimpanzees. Our study of the HERV-K family during Old World primate evolution contributes to the understanding of their possible biological functions in the host genomes.
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