Evidence map›Paper›PMID 9499029›Full record

ArticleJournal of virology1998

Effect of passive immunization or maternally transferred immunity on the antibody response to a genetic vaccine to rabies virus.

Y Wang, Z Xiang, S Pasquini, H C Ertl

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Development in Immunoprophylaxis against Rabies for Animals and Humans.Avicenna journal of medical biotechnology · 2010
    Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Y WangThe Wistar Institute, Philadelphia, Pennsylvania 19104-4268, USA.
Z Xiang
S Pasquini
H C Ertl
The Wistar Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A plasmid vector, termed pSG5rab.gp, expressing the glycoprotein of rabies virus was tested in young adult or neonatal mice in the presence of maternally transferred immunity or passively administered antibodies to rabies virus for induction of an antibody response. Mice born to rabies virus-immune dams developed an impaired antibody response to genetic immunization at 6 weeks of age, as had been previously observed upon vaccination with an inactivated viral vaccine. Similarly, mice passively immunized with hyperimmune serum showed an inhibited B-cell response upon vaccination with the pSG5rab.gp vector, resulting in both cases in vaccine failures upon challenge with a virulent strain of rabies virus. In contrast, the immune responses of mice vaccinated as neonates in the presence of maternal immunity or upon passive immunization to rabies virus with the pSG5rab.gp construct were only marginally affected.

Indexed as

Antigens, ViralAnimalsAnimals, NewbornAntibodies, ViralCell LineCricetinaeFemaleGlycoproteinsImmunity, Maternally-AcquiredImmunization, PassiveImmunoglobulin IsotypesMaleMiceMice, Inbred C3HRabies VaccinesRabies virusadenovirus 5, rabies glycoprotein recombinant vaccineAntibodies, ViralAntigens, Viralglycoprotein G, Rabies virusGlycoproteinsImmunoglobulin IsotypesRabies VaccinesVaccines, InactivatedVaccines, SyntheticViral Envelope Proteins

Identifiers

PMID9499029
PMCPMC109468
OpenAlexW1595781332

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.