ArticleImmunology1997
The high-affinity Fc gamma RI on PMN: regulation of expression and signal transduction.
Article in Immunology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 76 citations in OpenAlex.
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- A New Easy-to-Perform Flow Cytometry Assay for Determining Bacterial- and Viral-Infection-Induced Polymorphonuclear Neutrophil and Monocyte Membrane Marker Modulation in Febrile Patients.International journal of molecular sciences · 2024Article
- Therapeutic antibodies in oncology: an immunopharmacological overview.Cancer immunology, immunotherapy : CII · 2024Review
- Neutrophil CD64 index as a good biomarker for early diagnosis of bacterial infection in pregnant women during the flu season.Influenza and other respiratory viruses · 2023Article
- Real world population pharmacokinetic study in children and young adults with inflammatory bowel disease discovers novel blood and stool microbial predictors of vedolizumab clearance.Alimentary pharmacology & therapeutics · 2023Article
- Antibodies-to-infliximab accelerate clearance while dose intensification reverses immunogenicity and recaptures clinical response in paediatric Crohn's disease.Alimentary pharmacology & therapeutics · 2022Article
- Utility of neutrophil CD64 in distinguishing bacterial infection from inflammation in severe alcoholic hepatitis fulfilling SIRS criteria.Scientific reports · 2021Article
- Are Fc Gamma Receptor Polymorphisms Important in HIV-1 Infection Outcomes and Latent Reservoir Size?Frontiers in immunology · 2021Review
- Longitudinal characterization of olfactomedin-4 expressing neutrophils in pediatric patients undergoing bone marrow transplantation.PloS one · 2020Article
- Diagnostic performance of neutrophil CD64 index in patients with sepsis in the intensive care unit.The Journal of international medical research · 2019Article
- Utility of neutrophil CD64 and serum TREM-1 in distinguishing bacterial infection from disease flare in SLE and ANCA-associated vasculitis.Clinical rheumatology · 2019Article
- Recruitment of activated neutrophils correlates with disease severity in adult Crohn's disease.Clinical and experimental immunology · 2019Article
- Systemic and Intra-Nodal Activation of NK Cells After Rituximab Monotherapy for Follicular Lymphoma.Frontiers in immunology · 2019Article
- Progress Toward a Gonococcal Vaccine: The Way Forward.Frontiers in immunology · 2019Review
- Could Neutrophil CD64 Expression Be Used as a Diagnostic Parameter of Bacteremia in Patients with Febrile Neutropenia?Turkish journal of haematology : official journal of Turkish Society of Haematology · 2017Article
- Perioperative Increase in Neutrophil CD64 Expression is an Indicator for Intra-abdominal Infection after Colorectal Cancer Surgery.Radiology and oncology · 2017Article
- Role of cellular events in the pathophysiology of sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Review
- A Low Neutrophil CD64 Index Is Associated with Sustained Remission During Infliximab Maintenance Therapy.Inflammatory bowel diseases · 2016Article
- Markedly elevated CD64 expression on neutrophils and monocytes as a biomarker for diagnosis and therapy assessment in Kawasaki disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Mechanisms of action of therapeutic antibodies for cancer.Molecular immunology · 2015Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper we report that interferon-gamma (IFN-gamma) maintains and enhances functional properties of terminally differentiated polymorphonuclear cells (PMN). Such effects are obvious when compared with untreated PMN declining in their functional response. Culture for 18 hr with 100 IU/ml of recombinant IFN-gamma resulted in the expression of about 15,000 Fc gamma RI per PMN. IFN-gamma maintained viability of PMN and prevented reduction of Fc gamma RIIIb caused by apoptosis. No alterations were found in the level of Fc gamma RIIa. Next, functional properties of Fc gamma RI were evaluated. Calcium mobilization was detected in fura-2/acetoxymethylester (AM)-loaded PMN using a spectrophotometer and the respiratory burst was measured as luminol-dependent chemiluminescence. Cross-linking of an F(ab')2 fragment of monoclonal antibody (mAb) 22.2 to Fc gamma RI gave similar results to those obtained with intact monomeric human immunoglobulin G (mhIgG) when subsequently cross-linked. Moreover, after blocking Fc gamma RIIa and Fc gamma RIIIb with respective mAb fragments, mhIgG was still effective in triggering a calcium flux demonstrating that second messenger generation was caused by Fc gamma RI engagement. Even though Fc gamma RI expression was lower than that of Fc gamma RIIa, Fc gamma RI induced a higher increase of the respiratory burst. In addition, the protein tyrosine phosphatase CD45 was able to inhibit both responses when it was co-cross-linked with CD64, suggesting involvement of tyrosine phosphorylation in early signalling steps.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.