ArticleThe Journal of biological chemistry1998
Characterization of a cytosolic heat-shock protein-caveolin chaperone complex. Involvement in cholesterol trafficking.
Article in The Journal of biological chemistry, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 83 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 302 citations in OpenAlex.
- Identification of Cyclophilin A as a Potential Anticancer Target of Novel Nargenicin A1 Analog in AGS Gastric Cancer Cells.International journal of molecular sciences · 2021Article
- Cyclosporin A: A Repurposable Drug in the Treatment of COVID-19?Frontiers in medicine · 2021Review
- Characterization of physiochemical properties of caveolin-1 from normal and prion-infected human brains.Oncotarget · 2017Article
- Review
- Caveolae and Caveolin-1 Integrate Reverse Cholesterol Transport and Inflammation in Atherosclerosis.International journal of molecular sciences · 2016Review
- From embryonic development to human diseases: The functional role of caveolae/caveolin.Birth defects research. Part C, Embryo today : reviews · 2016Review
- Caveolae Restrict Tiger Frog Virus Release in HepG2 cells and Caveolae-Associated Proteins Incorporated into Virus Particles.Scientific reports · 2016Article
- Article
- β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice.Frontiers in cellular neuroscience · 2015Article
- Caveolin-1 in oral squamous cell carcinoma microenvironment: an overview.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- The Niemann-Pick C1 and caveolin-1 proteins interact to modulate efflux of low density lipoprotein-derived cholesterol from late endocytic compartments.Journal of molecular biochemistry · 2014Article
- Regulation of the trafficking and antiviral activity of IFITM3 by post-translational modifications.Future microbiology · 2014Review
- Apolipoprotein E gene polymorphism influences aggressive behavior in prostate cancer cells by deregulating cholesterol homeostasis.International journal of oncology · 2013Article
- Oligodendroglial process formation is differentially affected by modulating the intra- and extracellular cholesterol content.Journal of molecular neuroscience : MN · 2013Article
- Mandarin fish caveolin 1 interaction with major capsid protein of infectious spleen and kidney necrosis virus and its role in early stages of infection.Journal of virology · 2013Article
- Caveolar fatty acids and acylation of caveolin-1.PloS one · 2013Article
- Caveolin-1 reduces HIV-1 infectivity by restoration of HIV Nef mediated impairment of cholesterol efflux by apoA-I.Retrovirology · 2012Article
- S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus.The Journal of biological chemistry · 2012Article
- Regulation of cholesterol homeostasis.Cellular and molecular life sciences : CMLS · 2012Review
- Mitochondrial cholesterol: a connection between caveolin, metabolism, and disease.Traffic (Copenhagen, Denmark) · 2011Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2013-03-01Falsification/Fabrication of Image · Investigation by ORI · · See also: https://federalregister.gov/a/2012-28209
- Commented on by
- Commented on by
- Retracted
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Caveolin is a 22-kDa protein that appears to play a critical role in regulating the cholesterol concentration of caveolae. Even though caveolin is thought to be a membrane protein, several reports suggest that this peculiar protein can traffic independently of membrane vesicles. We now present evidence that a cytosolic pool of caveolin is part of a heat-shock protein-immunophilin chaperone complex consisting of caveolin, heat-shock protein 56, cyclophilin 40, cyclophilin A, and cholesterol. Treatment of NIH 3T3 cells with 1 microM cyclosporin A or 100 nM rapamycin disrupted the putative transport complex and prevented rapid (10-20 min) transport of cholesterol to caveolae. The lymphoid cell line, L1210-JF, does not express caveolin, does not form an immunophilin-caveolin complex, and does not transport newly synthesized cholesterol to caveolae. Transfection of caveolin cDNA into L1210-JF cells allowed the assembly of a transport complex identical to that found in NIH 3T3 cells. In addition, newly synthesized cholesterol in transfected cells was rapidly (10-20 min) and specifically transported to caveolae. These data strongly suggest that a caveolin-chaperone complex is a mechanism by which newly synthesized cholesterol is transported from the endoplasmic reticulum through the cytoplasm to caveolae.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.