ArticleAmerican journal of human genetics1998
Significance levels in complex inheritance.
Article in American journal of human genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
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- A defect in the CLIP1 gene (CLIP-170) can cause autosomal recessive intellectual disability.European journal of human genetics : EJHG · 2015Article
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- Linkage analysis in the next-generation sequencing era.Human heredity · 2011Review
- A pure likelihood approach to the analysis of genetic association data: an alternative to Bayesian and frequentist analysis.European journal of human genetics : EJHG · 2010Article
- A comparison of SNPs and microsatellites as linkage mapping markers: lessons from the zebra finch (Taeniopygia guttata).BMC genomics · 2010Article
- Child and adolescent psychiatric genetics.European child & adolescent psychiatry · 2010Review
- Genome-wide linkage analysis for uric acid in families enriched for hypertension.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2009Article
- Genomic susceptibility Loci for brain atrophy, ventricular volume, and leukoaraiosis in hypertensive sibships.Archives of neurology · 2009Article
- Identification of quantitative trait loci for fibrin clot phenotypes: the EuroCLOT study.Arteriosclerosis, thrombosis, and vascular biology · 2009Article
- Posterior probability of linkage analysis of autism dataset identifies linkage to chromosome 16.Psychiatric genetics · 2008Article
- Genetic aspects in attention-deficit/hyperactivity disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2008Review
- Evidence for a pleiotropic QTL on chromosome 5q13 influencing both time to asthma onset and asthma score in French EGEA families.Human genetics · 2007Article
- Inherited, familial and sporadic primary open-angle glaucoma.Journal of the National Medical Association · 2007Article
- Homozygosity mapping in consanguineous families reveals extreme heterogeneity of non-syndromic autosomal recessive mental retardation and identifies 8 novel gene loci.Human genetics · 2007Article
- Fifty years of genetic epidemiology, with special reference to Japan.Journal of human genetics · 2006Review
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- Genetic linkage of systemic lupus erythematosus to 13q32 in African American families with affected male members.Human genetics · 2005Article
- Ranks of genuine associations in whole-genome scans.Genetics · 2005Article
- Reliability of statistical associations between genes and disease.Immunogenetics · 2005Review
Corrections and comments
- Erratum issued
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A LOD score >=3 is necessary but not sufficient to make a linkage test reliable, and this applies to complex inheritance as well as to major loci. Factors that affect this threshold are considered here. A LOD score as small as 2 is suggestive but is unreliable except as confirmation of either a significant linkage or a strong candidate locus. A threshold as great as 4 is unnecessarily conservative if multipoint tests are used sensibly. Marker density is not a major factor, and biases in the evaluation of LOD scores-especially inadequate allowance for estimation of nuisance parameters in multiple models-are paramount. Allelic association increases resolution for oligogenes within a candidate region and remains the only practical method to locate polygenes. The method sketched here combines multipoint linkage and allelic association to test efficiently for a regional candidate locus.
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