ArticleThe Journal of eukaryotic microbiology
The evolutionary history of the genus Acanthamoeba and the identification of eight new 18S rRNA gene sequence types.
Article in The Journal of eukaryotic microbiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 1 of them a synthesis that pooled it.
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Who cites it
143 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genotype distribution of Acanthamoeba in keratitis: a systematic review.Parasitology research · 2021Pooled it
- Challenges in Diagnosing Acanthamoebae Infections Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry.Acta parasitologica · 2026Article
- Exploring novel thiazole-based minor groove binding agents as potential therapeutic agents against pathogenicRSC medicinal chemistry · 2025Article
- Molecular Typing ofMicroorganisms · 2025Article
- Navigating the Challenges of Acanthamoeba Keratitis: Current Trends and Future Directions.Life (Basel, Switzerland) · 2025Review
- Identification and Characterization of Acanthamoeba from Contact Lens Care Solutions and Hospital Environments in the Ophthalmology Wards and Operating Rooms in Southeastern Iran.Acta parasitologica · 2025Article
- Calcium ions in tap water may increase the adhesion ability of Acanthamoeba, potentially enhancing its cytopathic effects on corneal cells.Parasite (Paris, France) · 2025Article
- Comparative genomic analysis ofmSphere · 2024Article
- Learning from the rDNA Operon: A Reanalysis of theMicroorganisms · 2024Article
- First Report ofPathogens (Basel, Switzerland) · 2024Article
- Editorial for the Special Issue "Advances inMicroorganisms · 2024Article
- Understanding Acanthamoeba Keratitis: An In-Depth Review of a Sight-Threatening Eye Infection.Microorganisms · 2024Review
- Article
- Molecular detection and characterization of Acanthamoeba infection in dogs and its association with keratitis in Korea.Parasites, hosts and diseases · 2024Article
- Acanthamoeba Keratitis in China: Genotypic and Clinical Correlations.Translational vision science & technology · 2024Article
- Proteases of Acanthamoeba.Parasitology research · 2023Review
- Molecular evidence for a new lineage within the Acanthamoeba T4 genotype.Parasitology research · 2023Article
- The Status of Molecular Analyses of Isolates ofMicroorganisms · 2023Review
- Article
- An Insight into the Genome of Pathogenic and Non-PathogenicPathogens (Basel, Switzerland) · 2022Article
83 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
Abstract
The 18S rRNA gene (Rns) phylogeny of Acanthamoeba is being investigated as a basis for improvements in the nomenclature and taxonomy of the genus. We previously analyzed Rns sequences from 18 isolates from morphological groups 2 and 3 and found that they fell into four distinct evolutionary lineages we called sequence types T1-T4. Here, we analyzed sequences from 53 isolates representing 16 species and including 35 new strains. Eight additional lineages (sequence types T5-T12) were identified. Four of the 12 sequence types included strains from more than one nominal species. Thus, sequence types could be equated with species in some cases or with complexes of closely related species in others. The largest complex, sequence type T4, which contained six closely related nominal species, included 24 of 25 keratitis isolates. Rns sequence variation was insufficient for full phylogenetic resolution of branching orders within this complex, but the mixing of species observed at terminal nodes confirmed that traditional classification of isolates has been inconsistent. One solution to this problem would be to equate sequence types and single species. Alternatively, additional molecular information will be required to reliably differentiate species within the complexes. Three sequence types of morphological group 1 species represented the earliest divergence in the history of the genus and, based on their genetic distinctiveness, are candidates for reclassification as one or more novel genera.
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