ReviewCurrent opinion in immunology1997
Activation of autoreactive T cells by peptides from human pathogens.
Review in Current opinion in immunology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Potential clinical implications of molecular mimicry-induced autoimmunity.Immunity, inflammation and disease · 2024Review
- Cross-reactivity of T cells and its role in the immune system.Critical reviews in immunology · 2012Review
- Risk factors for chronic cerebrospinal venous insufficiency (CCSVI) in a large cohort of volunteers.PloS one · 2011Article
- Toll-like receptors in multiple sclerosis.Current topics in microbiology and immunology · 2009Review
- The cancer stem cell: evidence for its origin as an injured autoreactive T cell.Molecular cancer · 2006Review
- Private aspects of heterologous immunity.The Journal of experimental medicine · 2005Review
- Cross-reactivity between hepatitis C virus and Influenza A virus determinant-specific cytotoxic T cells.Journal of virology · 2001Article
- On the role of the innate immunity in autoimmune disease.The Journal of experimental medicine · 2001Article
- Autoimmunity. Thoughts for the millennium.Clinical reviews in allergy & immunology · 2000Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of autoreactive T cells is a necessary-but not sufficient-step in the development of T cell mediated autoimmunity. Autoreactive T cells can be activated by viral and bacterial peptides that meet the structural requirements for MHC molecule binding and T cell receptor recognition. Due to the degenerate nature of MHC class II molecule binding motifs and a certain degree of flexibility in T cell receptor recognition, such microbial peptides have been found to be quite distinct in their primary sequence from the self-peptide they mimic.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.