ArticleThe Journal of physiology1998
Convergence properties of solitary tract neurones driven synaptically by cardiac vagal afferents in the mouse.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- Consequences of peripheral chemoreflex inhibition with low-dose dopamine in humans.The Journal of physiology · 2014Trial
- Physiological Mechanisms of Hypertension and Cardiovascular Disease in End-Stage Kidney Disease.Current hypertension reports · 2022Review
- Advancing respiratory-cardiovascular physiology with the working heart-brainstem preparation over 25 years.The Journal of physiology · 2022Review
- Vagal Afferent Innervation of the Airways in Health and Disease.Physiological reviews · 2016Review
- Medullary Endocannabinoids Contribute to the Differential Resting Baroreflex Sensitivity in Rats with Altered Brain Renin-Angiotensin System Expression.Frontiers in physiology · 2016Article
- Alterations in the Medullary Endocannabinoid System Contribute to Age-related Impairment of Baroreflex Sensitivity.Journal of cardiovascular pharmacology · 2015Article
- Age-related reflex responses from peripheral and central chemoreceptors in healthy men.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2014Article
- Endogenous leptin contributes to baroreflex suppression within the solitary tract nucleus of aged rats.American journal of physiology. Heart and circulatory physiology · 2014Article
- Regulation of breathing and autonomic outflows by chemoreceptors.Comprehensive Physiology · 2014Review
- Inputs drive cell phenotype variability.Genome research · 2014Article
- Development of attenuated baroreflexes in obese Zucker rats coincides with impaired activation of nucleus tractus solitarius.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Nucleus of the solitary tract in the C57BL/6J mouse: Subnuclear parcellation, chorda tympani nerve projections, and brainstem connections.The Journal of comparative neurology · 2014Article
- Revelations about carotid body function through its pathological role in resistant hypertension.Current hypertension reports · 2013Review
- Regional differences in serotonin content in the nucleus of the solitary tract of male rats after hypovolemia produced by polyethylene glycol.The journal of physiological sciences : JPS · 2013Article
- Protein phosphatase 1b in the solitary tract nucleus is necessary for normal baroreflex function.Journal of cardiovascular pharmacology · 2012Article
- Interactions between epinephrine, ascending vagal fibers, and central noradrenergic systems in modulating memory for emotionally arousing events.Frontiers in behavioral neuroscience · 2012Article
- Hemodynamic and autonomic response to acute hemorrhage in streptozotocin-induced diabetic rats.Cardiovascular diabetology · 2010Article
- An essential component to brainstem cough gating identified in anesthetized guinea pigs.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Leptin impairs cardiovagal baroreflex function at the level of the solitary tract nucleus.Hypertension (Dallas, Tex. : 1979) · 2009Article
- Modulation of reflex function by endogenous angiotensins in older transgenic rats with low glial angiotensinogen.Hypertension (Dallas, Tex. : 1979) · 2008Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Cardiac vagal receptors are chemically and/or mechanically sensitive but it is unknown if this information is preserved centrally within the nucleus of the solitary tract (NTS). The present study had two aims: first, to investigate qualitatively whether both mechanically and chemically sensitive cardiac vagal encoding were preserved within the NTS, and second, to determine the patterns of convergence from other cardiorespiratory afferents to NTS neurones receiving cardiac vagal inputs. 2. The extracellular activity of single NTS neurones was investigated during stimulation of both chemically and mechanically sensitive cardiac vagal receptors in a working heart-brainstem preparation of mouse. Chemically sensitive cardiac receptors were stimulated using intra-left ventricular injections of either veratridine (1-3 microg kg-1), bradykinin (0.25-1 microg) or prostaglandin E2 (100-200 ng), whereas the left ventricle was distended to activate cardiac mechanoreceptors. 3. Forty-three NTS neurones were activated both synaptically by electrical stimulation of the ipsilateral vagus nerve (latency, 35 +/- 3 ms), and by intra-left ventricular injection of veratridine and also, in some cases, by bradykinin and/or PGE2. These NTS neurones were delineated into two populations based on their response to left ventricular distension and convergence properties. Left ventricular distension-insensitive neurones (n = 30) were excited by stimulation of carotid body chemoreceptors (81 %) but not arterial baroreceptors (3 %; i.e. n = 1 neurone), whereas distension-sensitive cells (n = 13) were activated mainly by baroreceptors (86 %) rather than peripheral chemoreceptors (14 %; i.e. n = 1 neurone). 4. The data reveal two distinct populations of NTS neurones receiving cardiac vagal inputs: (a) cells responsive to veratridine stimulation only, and (b) neurones activated by both veratridine and mechanical stimuli. The specific convergence pattern of baroreceptors and chemoreceptors to these cardioreceptive NTS neurones is discussed in relation to a common afferent modality integration within the NTS.
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