ArticleThe Journal of physiology1998
Cytoskeletal targeting of calponin in differentiated, contractile smooth muscle cells of the ferret.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- A primer on cancer-associated fibroblast mechanics and immunosuppressive ability.Exploration of targeted anti-tumor therapy · 2023Article
- Review
- Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders.Pharmacological reviews · 2016Review
- Cortical actin regulation modulates vascular contractility and compliance in veins.The Journal of physiology · 2015Article
- Vasoactive agonists exert dynamic and coordinated effects on vascular smooth muscle cell elasticity, cytoskeletal remodelling and adhesion.The Journal of physiology · 2014Article
- The role of actin filament dynamics in the myogenic response of cerebral resistance arteries.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Review
- Regulation of PKC autophosphorylation by calponin in contractile vascular smooth muscle tissue.BioMed research international · 2013Article
- Structure and dynamics of the actin-based smooth muscle contractile and cytoskeletal apparatus.Journal of muscle research and cell motility · 2012Review
- Deciphering actin cytoskeletal function in the contractile vascular smooth muscle cell.The Journal of physiology · 2012Review
- Tropomyosin variants describe distinct functional subcellular domains in differentiated vascular smooth muscle cells.American journal of physiology. Cell physiology · 2011Article
- Actin polymerization in differentiated vascular smooth muscle cells requires vasodilator-stimulated phosphoprotein.American journal of physiology. Cell physiology · 2010Article
- Smooth muscle signalling pathways in health and disease.Journal of cellular and molecular medicine · 2008Review
- Direct association of calponin with specific domains of PKC-alpha.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- Cytoskeletal remodeling in differentiated vascular smooth muscle is actin isoform dependent and stimulus dependent.American journal of physiology. Cell physiology · 2008Article
- Actin cytoskeletal dynamics in smooth muscle: a new paradigm for the regulation of smooth muscle contraction.American journal of physiology. Cell physiology · 2008Review
- Interactions of airway smooth muscle cells with their tissue matrix: implications for contraction.Proceedings of the American Thoracic Society · 2008Review
- Calponin is required for agonist-induced signal transduction--evidence from an antisense approach in ferret smooth muscle.The Journal of physiology · 2001Article
- Contractile properties and proteins of smooth muscles of a calponin knockout mouse.The Journal of physiology · 2000Article
- Protein kinase C isoenzymes: a review of their structure, regulation and role in regulating airways smooth muscle tone and mitogenesis.British journal of pharmacology · 2000Review
- Calponin interaction with alpha-actinin-actin: evidence for a structural role for calponin.Biophysical journal · 1999Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
1. Biochemical and quantitative image analysis methods were used to investigate the anatomical basis for the previously described agonist-induced redistribution of calponin. 2. At 140 nm resolution, the quantitative distribution of calponin in resting cells was statistically indistinguishable from that of filament bundles containing alpha-smooth muscle actin and myosin, but was significantly different from that of filaments containing beta-non-muscle actin. Conversely, in stimulated cells, the distribution of calponin was not significantly different from that of beta-actin filaments in the subplasmalemmal cell cortex but was significantly different from the distribution of alpha-actin- and myosin-containing filamentous bundles. 3. The distribution of calponin significantly differed from that of the intermediate filament proteins vimentin and desmin as well as that of the dense body protein alpha-actinin either by ratio analysis of the subcellular distribution or by colocalization analysis. 4. The imaging results, although limited to 140 nm spatial resolution, suggested the hypothesis that the agonist-induced redistribution involves the binding of calponin to isoform-specific actin filaments. This hypothesis was tested by quantifying the relative affinity of calponin for purified alpha- and beta-actin. Light scattering measurements showed that calponin induces bundle formation with beta-actin more readily than alpha-actin, indicating that calponin may be preferentially sequestered by beta-actin under appropriate conditions. 5. These results are consistent with a model whereby agonist activation decreases calponin's binding to filaments, but the tighter binding to beta-actin filaments results in a spatial redistribution of calponin to the submembranous cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.