ArticleThe Journal of physiology1998
alpha2-Adrenoceptor-mediated potassium currents in acutely dissociated rat locus coeruleus neurones.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 92 citations in OpenAlex.
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- Prenatal exposure to morphine enhances excitability in locus coeruleus neurons.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- The Nature of Noradrenergic Volume Transmission From Locus Coeruleus to Brainstem Mesencephalic Trigeminal Sensory Neurons.Frontiers in cellular neuroscience · 2022Article
- Preliminary evaluation of the efficacy and safety of brimonidine for general anesthesia.BMC anesthesiology · 2021Article
- Modulation of Noradrenergic and Serotonergic Systems by Cannabinoids: Electrophysiological, Neurochemical and Behavioral Evidence.Advances in experimental medicine and biology · 2021Article
- Bidirectional and context-dependent changes in theta and gamma oscillatory brain activity in noradrenergic cell-specific Hypocretin/Orexin receptor 1-KO mice.Scientific reports · 2018Article
- Chemogenetic and Optogenetic Activation of Gαs Signaling in the Basolateral Amygdala Induces Acute and Social Anxiety-Like States.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- The α2B-adrenergic receptor is mutant in cortical myoclonus and epilepsy.Annals of neurology · 2014Article
- Activation and inhibition of neurons in the hippocampal ventral subiculum by norepinephrine and locus coeruleus stimulation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Properties of slow oscillation during slow-wave sleep and anesthesia in cats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Spontaneous spiking and synaptic depression underlie noradrenergic control of feed-forward inhibition.Neuron · 2011Article
- Excitation of locus coeruleus noradrenergic neurons by thyrotropin-releasing hormone.The Journal of physiology · 2009Article
- Firing activity of locus coeruleus noradrenergic neurons increases in a rodent model of Parkinsonism.Neuroscience bulletin · 2009Article
- Noradrenergic modulation of basolateral amygdala neuronal activity: opposing influences of alpha-2 and beta receptor activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The noradrenaline (NA)-activated response was investigated in neurones acutely dissociated from the rat locus coeruleus (LC) using nystatin-perforated, conventional whole-cell and inside-out patch recording modes under current- and voltage-clamp conditions. 2. Under current-clamp conditions, NA hyperpolarized the LC neurones, abolishing the spontaneous action potentials. In voltage-clamp studies, NA induced an inwardly rectifying K+ current (INA) in a concentration-dependent manner with a half-maximum effective concentration of 2.2 x 10(-7) M. 3. INA was mimicked by the alpha2-agonist UK14304 but was inhibited by either the alpha2B/alpha2C antagonist ARC239 or the alpha1- and alpha2B/alpha2C antagonist prazosin, suggesting the contribution of alpha2B/alpha2C adrenoceptors. 4. INA was inhibited by the intracellular application of GDPbetaS but fully activated by intracellular perfusion of GTPgammaS. 5. In the inside-out recording mode, the application of GTP to the cytoplasmic side of the patch membrane markedly enhanced the open probability of the NA-activated single channels which represented the inwardly rectifying properties. 6. These results indicate that the activation of alpha2B/alpha2C adrenoceptors coupled with GTP-binding protein directly activates the inwardly rectifying K+ currents in rat LC neurones, thus resulting in a decrease in the spontaneous firing activities.
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