ArticleThe Plant cell1998
Alpha-tubulin missense mutations correlate with antimicrotubule drug resistance in Eleusine indica.
Article in The Plant cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 105 citations in OpenAlex.
- Deep haplotype analyses of target-site resistance locus ACCase in blackgrass enabled by pool-based amplicon sequencing.Plant biotechnology journal · 2023Article
- Genome-Wide Identification and Expression Analysis ofPlants (Basel, Switzerland) · 2022Article
- Identification of two Eleusine indica (goosegrass) biotypes of cool-season turfgrass resistant to dithiopyr.Pest management science · 2022Article
- The Development of Herbicide Resistance Crop Plants Using CRISPR/Cas9-Mediated Gene Editing.Genes · 2021Review
- Dinitroaniline Herbicide Resistance and Mechanisms in Weeds.Frontiers in plant science · 2021Review
- Developing a novel artificial rice germplasm for dinitroaniline herbicide resistance by base editing of OsTubA2.Plant biotechnology journal · 2021Article
- Transketolase Is Identified as a Target of Herbicidal Substance α-Terthienyl by Proteomics.Toxins · 2018Article
- Novel α-Tubulin Mutations Conferring Resistance to Dinitroaniline Herbicides inFrontiers in plant science · 2018Article
- Semi-dwarfism and lodging tolerance in tef (Eragrostis tef) is linked to a mutation in the α-Tubulin 1 gene.Journal of experimental botany · 2015Article
- Microtubule drugs: action, selectivity, and resistance across the kingdoms of life.Protoplasma · 2014Review
- Protein change in plant evolution: tracing one thread connecting molecular and phenotypic diversity.Frontiers in plant science · 2013Review
- De novo assembly and characterization of the Barnyardgrass (Echinochloa crus-galli) transcriptome using next-generation pyrosequencing.PloS one · 2013Article
- α-Tubulin mutations alter oryzalin affinity and microtubule assembly properties to confer dinitroaniline resistance.Eukaryotic cell · 2010Article
- Mutations in alpha-tubulin confer dinitroaniline resistance at a cost to microtubule function.Molecular biology of the cell · 2007Article
- Molecular bases for sensitivity to tubulin-binding herbicides in green foxtail.Plant physiology · 2004Article
- Dinitroanilines bind alpha-tubulin to disrupt microtubules.Molecular biology of the cell · 2004Article
- The Arabidopsis cytoskeletal genome.The arabidopsis book · 2003Article
- Plant tubulins: a melting pot for basic questions and promising applications.Transgenic research · 2000Review
- Molecular characterization of four beta-tubulin genes from dinitroaniline susceptible and resistant biotypes of Eleusine indica.Plant molecular biology · 1999Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dinitroaniline herbicides are antimicrotubule drugs that bind to tubulins and inhibit polymerization. As a result of repeated application of dinitroaniline herbicides, highly resistant and intermediately resistant biotypes of goosegrass (Eleusine indica) developed in previously wild-type populations. Three alpha-tubulin cDNA classes (designated TUA1, TUA2, and TUA3) were isolated from each biotype. Nucleotide differences between the susceptible and the resistant (R) alpha-tubulins were identified in TUA1 and TUA2. The most significant differences were missense mutations that occurred in TUA1 of the R and intermediately resistant (I) biotypes. Such mutations convert Thr-239 to Ile in the R biotype and Met-268 to Thr in the I biotype. These amino acid substitutions alter hydrophobicity; therefore, they may alter the dinitroaniline binding property of the protein. These mutations were correlated with the dinitroaniline response phenotypes (Drp). Plants homozygous for susceptibility possessed the wild-type TUA1 allele; plants homozygous for resistance possessed the mutant tua1 allele; and plants heterozygous for susceptibility possessed both wild-type and mutant alleles. Thus, we conclude that TUA1 is at the Drp locus. Using polymerase chain reaction primer-introduced restriction analysis, we demonstrated that goosegrass genomic DNA can be diagnosed for Drp alleles. Although not direct proof, these results suggest that a mutation in an alpha-tubulin gene confers resistance to dinitroanilines in goosegrass.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.