ArticleThe Plant cell1998
2,4-Dichlorophenoxybutyric acid-resistant mutants of Arabidopsis have defects in glyoxysomal fatty acid beta-oxidation.
Article in The Plant cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers.
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Who cites it
142 citing papers in PubMed, 277 citations in OpenAlex.
- Structural insights into Arabidopsis thaliana CTS-mediated fatty acid and hormone metabolism.Nature communications · 2026Article
- PEX11 mediates intralumenal vesicle formation in peroxisomes.Nature communications · 2026Article
- Cryo-SEM and large volume FIB-SEM of Arabidopsis cotyledons: Degradation of lipid bodies, biogenesis of glyoxysomes and reorganisation of organelles during germination.Journal of microscopy · 2025Article
- Identifying and characterizing a missing peroxin-PEX8-in Arabidopsis thaliana.The Plant cell · 2025Article
- The Atypical Pectin Methylesterase Family Member PME31 Promotes Seedling Lipid Droplet Utilization.Plant direct · 2025Article
- TALE-based C-to-T base editor for multiple homologous genes with flexible precision.Plant biotechnology (Tokyo, Japan) · 2024Article
- An auxin research odyssey: 1989-2023.The Plant cell · 2024Review
- Fusing the 3'UTR of seed storage protein genes leads to massive recombinant protein accumulation in seeds.Scientific reports · 2023Article
- The ubiquitin-protein ligase MIEL1 localizes to peroxisomes to promote seedling oleosin degradation and lipid droplet mobilization.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Peroxisomal KAT2 (3-ketoacyl-CoA thiolase 2) gene has a key role in gingerol biosynthesis in ginger (Journal of plant biochemistry and biotechnology · 2023Article
- Article
- An Arabidopsis pre-RNA processing8a (prp8a) missense allele restores splicing of a subset of mis-spliced mRNAs.Plant physiology · 2022Article
- Ubiquitin-conjugating activity by PEX4 is required for efficient protein transport to peroxisomes in Arabidopsis thaliana.The Journal of biological chemistry · 2022Article
- Leaf-size control beyond transcription factors: Compensatory mechanisms.Frontiers in plant science · 2022Review
- Skotomorphogenesis exploits threonine to promote hypocotyl elongation.Quantitative plant biology · 2022Article
- Image-Based Analysis Revealing the Molecular Mechanism of Peroxisome Dynamics in Plants.Frontiers in cell and developmental biology · 2022Review
- Regional association analysis coupled with transcriptome analyses reveal candidate genes affecting seed oil accumulation in Brassica napus.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Long chain acyl CoA synthetase 4 catalyzes the first step in peroxisomal indole-3-butyric acid to IAA conversion.Plant physiology · 2021Article
- Quantitative Proteomics and Transcriptomics Reveals Differences in Proteins During Anthers Development inFrontiers in plant science · 2021Article
- Metabolic Alterations in the Enoyl-CoA Hydratase 2 Mutant Disrupt Peroxisomal Pathways in Seedlings.Plant physiology · 2019Article
82 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been demonstrated previously that 2,4-dichlorophenoxybutyric acid (2,4-DB) is metabolized to produce a herbicide, 2,4-D, by the action of peroxisomal fatty acid beta-oxidation in higher plants. To isolate mutants that have defects in peroxisomal fatty acid beta-oxidation, we screened mutant lines of Arabidopsis seedlings for growth in the presence of toxic levels of 2,4-DB. Twelve of the mutants survived; of these, four required sucrose for postgerminative growth. This result suggests that these mutants have defects in peroxisomal fatty acid beta-oxidation, because peroxisomal fatty acid beta-oxidation plays an important role in producing sucrose from storage lipids during germination. Genetic analysis revealed that these mutants can be classified as carrying alleles at three independent loci, which we designated ped1, ped2, and ped3, respectively (where ped stands for peroxisome defective). The ped1 mutant lacks the thiolase protein, an enzyme involved in fatty acid beta-oxidation during germination and subsequent seedling growth, whereas the ped2 mutant has a defect in the intracellular transport of thiolase from the cytosol to glyoxysomes. Etiolated cotyledons of both ped1 and ped2 mutants have glyoxysomes with abnormal morphology.
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