ArticleThe Journal of cell biology1998
Regulation of neural cell adhesion molecule polysialylation: evidence for nontranscriptional control and sensitivity to an intracellular pool of calcium.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 70 citations in OpenAlex.
- Spatiotemporal differential regulation of extrasynaptic GluN2B receptor subunits and PSA-NCAM in brain aging and Alzheimer's disease.Frontiers in neuroscience · 2025Article
- Polysialic Acid in the Immune System.Frontiers in immunology · 2021Review
- Ketamine and Calcium Signaling-A Crosstalk for Neuronal Physiology and Pathology.International journal of molecular sciences · 2020Review
- Expression of neural cell adhesion molecule and polysialic acid in human bone marrow-derived mesenchymal stromal cells.Stem cell research & therapy · 2016Article
- A human anti-polysialic acid antibody as a potential treatment to improve function in multiple sclerosis patients.Journal of nature and science · 2015Article
- Abnormal cartilage development and altered N-glycosylation in Tmem165-deficient zebrafish mirrors the phenotypes associated with TMEM165-CDG.Glycobiology · 2015Article
- Withania somnifera water extract as a potential candidate for differentiation based therapy of human neuroblastomas.PloS one · 2013Article
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- N-CAM dysfunction and unexpected accumulation of PSA-NCAM in brain of adult-onset autosomal-dominant leukodystrophy.Brain pathology (Zurich, Switzerland) · 2010Article
- Synthesis and structural characterization of sialic acid-glutamic acid hybrid foldamers as conformational surrogates of alpha-2,8-linked polysialic acid.Journal of the American Chemical Society · 2009Article
- Intrinsic role of polysialylated neural cell adhesion molecule in photic phase resetting of the Mammalian circadian clock.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- NMDA receptor and nitric oxide synthase activation regulate polysialylated neural cell adhesion molecule expression in adult brainstem synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Retinoic acid induction of sialyltransferase activity in neuroblastoma cells of differing sialylation potentials.Glycoconjugate journal · 2000Article
- Negative regulation of central nervous system myelination by polysialylated-neural cell adhesion molecule.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Morphofunctional plasticity in the adult hypothalamus induces regulation of polysialic acid-neural cell adhesion molecule through changing activity and expression levels of polysialyltransferases.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- The pattern of avian intramuscular nerve branching is determined by the innervating motoneuron and its level of polysialic acid.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Overexpression of alpha2,3 sialyltransferase in neuroblastoma cells results in an upset in the glycosylation process.Glycoconjugate journal · 1999Article
- Neuromuscular activity blockade induced by muscimol and d-tubocurarine differentially affects the survival of embryonic chick motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The up- and downregulation of polysialic acid-neural cell adhesion molecule (PSA-NCAM) expression on motorneurons during development is associated respectively with target innervation and synaptogenesis, and is regulated at the level of PSA enzymatic biosynthesis involving specific polysialyltransferase activity. The purpose of this study has been to describe the cellular mechanisms by which that regulation might occur. It has been found that developmental regulation of PSA synthesis by ciliary ganglion motorneurons is not reflected in the levels of polysialyltransferase-1 (PST) or sialyltransferase-X (STX) mRNA. On the other hand, PSA synthesis in both the ciliary ganglion and the developing tectum appears to be coupled to the concentration of calcium in intracellular compartments. This study documents a calcium dependence of polysialyltransferase activity in a cell-free assay over the range of 0.1-1 mM, and a rapid sensitivity of new PSA synthesis, as measured in a pulse-chase analysis of tissue explants, to calcium ionophore perturbation of intracellular calcium levels. Moreover, the relevant calcium pool appears to be within a specific intracellular compartment that is sensitive to thapsigargin and does not directly reflect the level of cytosolic calcium. Perturbation of other major second messenger systems, such as cAMP and protein kinase-dependent pathways, did not affect polysialylation in the pulse chase analysis. These results suggest that the shuttling of calcium to different pools within the cell can result in the rapid regulation of PSA synthesis in developing tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.