ArticleThe Journal of cell biology1998
A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed.
- Synthetic Antibodies Detect Distinct Cellular States of Chromosome Passenger Complex Proteins.Journal of molecular biology · 2022Article
- Functional midbody assembly in the absence of a central spindle.The Journal of cell biology · 2022Article
- Cell cycle-independent furrowing triggered by phosphomimetic mutations of the INCENP STD motif requires Plk1.Journal of cell science · 2019Article
- Chromosomal passenger complex hydrodynamics suggests chaperoning of the inactive state by nucleoplasmin/nucleophosmin.Molecular biology of the cell · 2017Article
- Large tumor suppressors 1 and 2 regulate Aurora-B through phosphorylation of INCENP to ensure completion of cytokinesis.Heliyon · 2016Article
- The Dawn of Aurora Kinase Research: From Fly Genetics to the Clinic.Frontiers in cell and developmental biology · 2015Review
- EB1 enables spindle microtubules to regulate centromeric recruitment of Aurora B.The Journal of cell biology · 2014Article
- Review
- A regulatory effect of INMAP on centromere proteins: antisense INMAP induces CENP-B variation and centromeric halo.PloS one · 2014Article
- The long coiled-coil protein NECC2 is associated to caveolae and modulates NGF/TrkA signaling in PC12 cells [corrected].PloS one · 2013Article
- The chromosomal passenger complex is required for meiotic acentrosomal spindle assembly and chromosome biorientation.Genetics · 2012Article
- Aurora B is regulated by the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway and is a valuable potential target in melanoma cells.The Journal of biological chemistry · 2012Article
- Unsupervised modeling of cell morphology dynamics for time-lapse microscopy.Nature methods · 2012Article
- Actin filament severing by cofilin is more important for assembly than constriction of the cytokinetic contractile ring.The Journal of cell biology · 2011Article
- Correction of microtubule-kinetochore attachment errors: mechanisms and role in tumor suppression.Seminars in cell & developmental biology · 2011Review
- Chromosome passenger complexes control anaphase duration and spindle elongation via a kinesin-5 brake.The Journal of cell biology · 2011Article
- E2 ligase dRad6 regulates DMP53 turnover in Drosophila.The Journal of biological chemistry · 2011Article
- Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition.Molecular & cellular proteomics : MCP · 2010Article
- The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.The Journal of cell biology · 2009Article
- INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization.The Journal of cell biology · 2009Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
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Abstract
INCENP is a tightly bound chromosomal protein that transfers to the spindle midzone at the metaphase/anaphase transition. Here, we show that an INCENP truncation mutant (INCENP382-839) associates with microtubules but does not bind to chromosomes, and coats the entire spindle throughout mitosis. Furthermore, an INCENP truncation mutant (INCENP43-839) previously shown not to transfer to the spindle at anaphase (Mackay, A.M., D.M. Eckley, C. Chue, and W.C. Earnshaw. 1993. J. Cell Biol. 123:373-385), is shown here to bind chromosomes, but is unable to target to the centromere. Thus, association with the chromosomes, and specifically with centromeres, appears to be essential for INCENP targeting to the correct spindle subdomain at anaphase. An INCENP truncation mutant (INCENP1-405) that targets to centromeres but lacks the microtubule association region acquires strong dominant-negative characteristics. INCENP1-405 interferes with both prometaphase chromosome alignment and the completion of cytokinesis. INCENP1-405 apparently exerts its effect by displacing the endogenous protein from centromeres. These experiments provide evidence of an unexpected link between this chromosomal protein and cytokinesis, and suggest that one function of INCENP may be to integrate the chromosomal and cytoskeletal events of mitosis.
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