ArticleMolecular and cellular biology1998
Cloning and biochemical characterization of TAF-172, a human homolog of yeast Mot1.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 68 citations in OpenAlex.
- BTAF1: a key regulator of DNA end resection and predictor of chemotherapy sensitivity in gastric cancer.Cell death and differentiation · 2026Article
- Article
- Molecular Mechanism of Mot1, a TATA-binding Protein (TBP)-DNA Dissociating Enzyme.The Journal of biological chemistry · 2016Article
- Mot1 redistributes TBP from TATA-containing to TATA-less promoters.Molecular and cellular biology · 2013Article
- Interconversion between active and inactive TATA-binding protein transcription complexes in the mouse genome.Nucleic acids research · 2012Article
- One small step for Mot1; one giant leap for other Swi2/Snf2 enzymes?Biochimica et biophysica acta · 2011Review
- TBP-related factors: a paradigm of diversity in transcription initiation.Cell & bioscience · 2011Article
- Genome-wide transcriptional dependence on conserved regions of Mot1.Molecular and cellular biology · 2011Article
- A proteomics analysis of yeast Mot1p protein-protein associations: insights into mechanism.Molecular & cellular proteomics : MCP · 2008Article
- HARP is an ATP-driven annealing helicase.Science (New York, N.Y.) · 2008Article
- Computational modelling of genome-wide [corrected] transcription assembly networks using a fluidics analogy.PloS one · 2008Article
- Molecular basis for repression of liver X receptor-mediated gene transcription by receptor-interacting protein 140.The Biochemical journal · 2007Article
- A TATA binding protein regulatory network that governs transcription complex assembly.Genome biology · 2007Article
- Article
- Identification of multiple distinct Snf2 subfamilies with conserved structural motifs.Nucleic acids research · 2006Article
- Mutational analysis of BTAF1-TBP interaction: BTAF1 can rescue DNA-binding defective TBP mutants.Nucleic acids research · 2005Article
- NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein.Molecular and cellular biology · 2004Article
- Quantitative sequential chromatin immunoprecipitation, a method for analyzing co-occupancy of proteins at genomic regions in vivo.Nucleic acids research · 2004Article
- High-affinity DNA binding by a Mot1p-TBP complex: implications for TAF-independent transcription.The EMBO journal · 2003Article
- Structural and functional analysis of mutations along the crystallographic dimer interface of the yeast TATA binding protein.Molecular and cellular biology · 2003Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The TATA binding protein (TBP) is a central component of the eukaryotic transcriptional machinery and is the target of positive and negative transcriptional regulators. Here we describe the cloning and biochemical characterization of an abundant human TBP-associated factor (TAF-172) which is homologous to the yeast Mot1 protein and a member of the larger Snf2/Swi2 family of DNA-targeted ATPases. Like Mot1, TAF-172 binds to the conserved core of TBP and uses the energy of ATP hydrolysis to dissociate TBP from DNA (ADI activity). Interestingly, ATP also causes TAF-172 to dissociate from TBP, which has not been previously observed with Mot1. Unlike Mot1, TAF-172 requires both TBP and DNA for maximal (approximately 100-fold) ATPase activation. TAF-172 inhibits TBP-driven RNA polymerase II and III transcription but does not appear to affect transcription driven by TBP-TAF complexes. As it does with Mot1, TFIIA reverses TAF-172-mediated repression of TBP. Together, these findings suggest that human TAF-172 is the functional homolog of yeast Mot1 and uses the energy of ATP hydrolysis to remove TBP (but apparently not TBP-TAF complexes) from DNA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.